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MedKoo Cat#: 561558 | Name: Polydatin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Polydatin is an inhibitor of platelet aggregation that works by inhibiting ICAM-1 expression, elevating Ca2+, weakening white blood cell-endothelial cell adhesion, and activating KATP channels.

Chemical Structure

Polydatin
Polydatin
CAS#27208-80-6

Theoretical Analysis

MedKoo Cat#: 561558

Name: Polydatin

CAS#: 27208-80-6

Chemical Formula: C20H22O8

Exact Mass: 390.1315

Molecular Weight: 390.39

Elemental Analysis: C, 61.53; H, 5.68; O, 32.79

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
2g USD 350.00 2 Weeks
5g USD 650.00 2 Weeks
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Related CAS #
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Synonym
Polydatin; Piceid; trans-Polydatin; 3,4,5-Tsg; (E)-Piceid; (E)-Polydatin
IUPAC/Chemical Name
(2S,3R,4S,5S,6R)-2-[3-Hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
InChi Key
HSTZMXCBWJGKHG-CUYWLFDKSA-N
InChi Code
InChI=1S/C20H22O8/c21-10-16-17(24)18(25)19(26)20(28-16)27-15-8-12(7-14(23)9-15)2-1-11-3-5-13(22)6-4-11/h1-9,16-26H,10H2/b2-1+/t16-,17-,18+,19-,20-/m1/s1
SMILES Code
O[C@H]1[C@H](OC2=CC(/C=C/C3=CC=C(O)C=C3)=CC(O)=C2)O[C@H](CO)[C@@H](O)[C@@H]1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Polydatin is an inhibitor of platelet aggregation that works by inhibiting ICAM-1 expression, elevating Ca2+, weakening white blood cell-endothelial cell adhesion, and activating KATP channels.
In vitro activity:
This study aimed to explore the protective effect of polydatin (PD) on the radon-exposed injury. The results showed that PD can significantly reduce ROS level, raise SOD activity, weaken the migration ability, increase E-cad, and decrease mesenchymal cell surface markers (FN1, Vimentin, N-cad, α-SMA, and Snail) in radon-exposed epithelial cells. Compared with directly adding PD on radon-exposed cells, adding PD before and after radon exposure could more obviously improve the adhesion of radon-exposed cells, significantly alleviate the migration ability, and more significantly reduce mesenchyme markers and p-AKT and p-mTOR. Reference: Dose Response. 2023 Apr 24;21(2):15593258231172271. https://pubmed.ncbi.nlm.nih.gov/37123604/
In vivo activity:
To investigate the possible mechanism of this action, this study determined the effects of polydatin on the expression of cell adhesion molecules (CAMs) after ischemia-induced cerebral injury. Rats were treated with polydatin (i.v.) immediately after the operation of middle cerebral artery occlusion (MCAO) for 1 h. It was found that polydatin improved neurological deficits and reduced the volume of brain infarction. In addition, polydatin decreased the levels of CAMs relative to the control (MCAO alone); these included intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, L-selectin and Integrins. Reference: Brain Res. 2006 Sep 19;1110(1):193-200. https://pubmed.ncbi.nlm.nih.gov/16870162/
Solvent mg/mL mM comments
Solubility
DMF 50.0 128.08
DMSO 45.7 116.98
Ethanol 30.0 76.85
PBS (pH 7.2) 0.3 0.64
Water 0.1 0.26
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 390.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Chen H, Luo F, Song H, Long H, Chen N, Sun L, Cui F, Wan J, Tu Y. Radiation Protection of Polydatin Against Radon Exposure Injury of Epithelial Cells and Mice. Dose Response. 2023 Apr 24;21(2):15593258231172271. doi: 10.1177/15593258231172271. PMID: 37123604; PMCID: PMC10134130. 2. Li XH, Gong X, Zhang L, Jiang R, Li HZ, Wu MJ, Wan JY. Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1. Mediators Inflamm. 2013;2013:354087. doi: 10.1155/2013/354087. Epub 2013 Jan 30. PMID: 23431240; PMCID: PMC3570923. 3. Demirkapi EN, Ince S, Demirel HH, Arslan-Acaroz D, Acaroz U. Polydatin reduces aflatoxin-B1 induced oxidative stress, DNA damage, and inflammatory cytokine levels in mice. Environ Sci Pollut Res Int. 2023 May 8. doi: 10.1007/s11356-023-27361-y. Epub ahead of print. PMID: 37155108. 4. Cheng Y, Zhang HT, Sun L, Guo S, Ouyang S, Zhang Y, Xu J. Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury. Brain Res. 2006 Sep 19;1110(1):193-200. doi: 10.1016/j.brainres.2006.06.065. Epub 2006 Jul 25. PMID: 16870162.
In vitro protocol:
1. Chen H, Luo F, Song H, Long H, Chen N, Sun L, Cui F, Wan J, Tu Y. Radiation Protection of Polydatin Against Radon Exposure Injury of Epithelial Cells and Mice. Dose Response. 2023 Apr 24;21(2):15593258231172271. doi: 10.1177/15593258231172271. PMID: 37123604; PMCID: PMC10134130. 2. Li XH, Gong X, Zhang L, Jiang R, Li HZ, Wu MJ, Wan JY. Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1. Mediators Inflamm. 2013;2013:354087. doi: 10.1155/2013/354087. Epub 2013 Jan 30. PMID: 23431240; PMCID: PMC3570923.
In vivo protocol:
1. Demirkapi EN, Ince S, Demirel HH, Arslan-Acaroz D, Acaroz U. Polydatin reduces aflatoxin-B1 induced oxidative stress, DNA damage, and inflammatory cytokine levels in mice. Environ Sci Pollut Res Int. 2023 May 8. doi: 10.1007/s11356-023-27361-y. Epub ahead of print. PMID: 37155108. 2. Cheng Y, Zhang HT, Sun L, Guo S, Ouyang S, Zhang Y, Xu J. Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury. Brain Res. 2006 Sep 19;1110(1):193-200. doi: 10.1016/j.brainres.2006.06.065. Epub 2006 Jul 25. PMID: 16870162.
1: Zhu F, Dai J, Yan Z, Xu Q, Ma M, Chen N, Liu D, Zang Y. Engineering regioselectivity of glycosyltransferase for efficient polydatin synthesis. Food Chem. 2024 Jul 31;460(Pt 2):140698. doi: 10.1016/j.foodchem.2024.140698. Epub ahead of print. PMID: 39098192. 2: Zhang Y, Qiu JQ, Wei X, Lei X, Tang YY, Qu Q, Zhao XM, Zhang XB, Sun J, Luo W, Song X. [Extraction process optimization and link evaluation of Reyanning Mixture based on quality by design idea]. Zhongguo Zhong Yao Za Zhi. 2024 Jun;49(12):3229-3241. Chinese. doi: 10.19540/j.cnki.cjcmm.20240313.302. PMID: 39041084. 3: Chen G, Zhang S, Wang X, Fan X, Wilson G, Sa Y, Ma X. A strategy for inhibitors screening of xanthine oxidase based on colorimetric sensor combined with affinity chromatography technology. Biosens Bioelectron. 2024 Oct 1;261:116510. doi: 10.1016/j.bios.2024.116510. Epub 2024 Jun 17. PMID: 38905859. 4: Liang L, Zeng J, Liu R, Zheng Z, Lyu D, Zhang X, Wen M, Li M, Xiao H, Sun X, Li M, Huang H. Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway. Biochem Pharmacol. 2024 Aug;226:116373. doi: 10.1016/j.bcp.2024.116373. Epub 2024 Jun 15. PMID: 38885772. 5: He J, Qian YC, Yin YC, Kang JR, Pan TR. Polydatin: a potential NAFLD therapeutic drug that regulates mitochondrial autophagy through SIRT3-FOXO3-BNIP3 and PINK1-PRKN mechanisms - a network pharmacology and experimental investigation. Chem Biol Interact. 2024 Aug 1;398:111110. doi: 10.1016/j.cbi.2024.111110. Epub 2024 Jun 13. PMID: 38876248. 6: Wu S, Zhao Q, Liu S, Kuang J, Zhang J, Onga A, Shen Y, Wang J, Sui H, Ni L, Ye Y, Tu X, Le HB, Zheng Y, Cui R, Zhu W. Polydatin, a potential NOX5 agonist, synergistically enhances antitumor activity of cisplatin by stimulating oxidative stress in non‑small cell lung cancer. Int J Oncol. 2024 Aug;65(2):77. doi: 10.3892/ijo.2024.5665. Epub 2024 Jun 14. PMID: 38873997; PMCID: PMC11251743. 7: Lin Y, Lu H, Jia Q, Han S. Screening anti-anaphylactoid components in Polygonum cuspidatum via cell membrane chromatography with LC-MS targeting Mas- related G protein-coupled receptor X2. J Sep Sci. 2024 Jun;47(11):e2300924. doi: 10.1002/jssc.202300924. PMID: 38819784. 8: Yalkun I, Wan H, Ye L, Yu L, He Y, Li C, Wan H. Qualitative and Quantitative Analysis of Chemical Components in Yinhua Pinggan Granule with High-Performance Liquid Chromatography Coupled with Q-Exactive Mass Spectrometry. Molecules. 2024 May 14;29(10):2300. doi: 10.3390/molecules29102300. PMID: 38792164; PMCID: PMC11124461. 9: Cilleros-Holgado P, Gómez-Fernández D, Piñero-Pérez R, Romero Domínguez JM, Talaverón-Rey M, Reche-López D, Suárez-Rivero JM, Álvarez-Córdoba M, Romero- González A, López-Cabrera A, Oliveira MC, Rodríguez-Sacristan A, Sánchez-Alcázar JA. Polydatin and Nicotinamide Rescue the Cellular Phenotype of Mitochondrial Diseases by Mitochondrial Unfolded Protein Response (mtUPR) Activation. Biomolecules. 2024 May 18;14(5):598. doi: 10.3390/biom14050598. PMID: 38786005; PMCID: PMC11118892. 10: Chi F, Cheng C, Zhang M, Su B, Hou Y, Bai G. Resveratrol targeting NRF2 disrupts the binding between KEAP1 and NRF2-DLG motif to ameliorate oxidative stress damage in mice pulmonary infection. J Ethnopharmacol. 2024 Oct 5;332:118353. doi: 10.1016/j.jep.2024.118353. Epub 2024 May 16. PMID: 38762209. 11: Ingrà C, Del Frari G, Favole M, Tumminelli E, Rossi D, Collina S, Prati M, Ferreira RB, Ferrandino A. Effects of Growing Areas, Pruning Wound Protection Products, and Phenological Stage on the Stilbene Composition of Grapevine (Vitis vinifera L.) Canes. J Agric Food Chem. 2024 May 22;72(20):11465-11479. doi: 10.1021/acs.jafc.4c00583. Epub 2024 May 13. PMID: 38739781. 12: Liu K, Liu J, Xu A, Ding J. The role of polydatin in inhibiting oxidative stress through SIRT1 activation: A comprehensive review of molecular targets. J Ethnopharmacol. 2024 Sep 15;331:118322. doi: 10.1016/j.jep.2024.118322. Epub 2024 May 8. PMID: 38729537. 13: Idoudi S, Tourrette A, Bouajila J, Romdhane M, Elfalleh W. The genus Polygonum: An updated comprehensive review of its ethnomedicinal, phytochemical, pharmacological activities, toxicology, and phytopharmaceutical formulation. Heliyon. 2024 Apr 6;10(8):e28947. doi: 10.1016/j.heliyon.2024.e28947. PMID: 38638945; PMCID: PMC11024578. 14: Ruan L, Zheng M, Xia X, Pang C, Wang Y, Fan Z, Yang J, Qing Q, Lin H, Tao Y, Wang J, Wang L. Exploring the Constituents and Mechanisms of Polygonum multiflorum Thunb. in Mitigating Ischemic Stroke: A Network Pharmacology and Molecular Docking Study. Comb Chem High Throughput Screen. 2024 Apr 15. doi: 10.2174/0113862073285988240229081558. Epub ahead of print. PMID: 38623977. 15: Ye Z, Lin J, He C, Yu P, Cao G, Shen Q, Wang C. Polydatin protects against articular cartilage degeneration by regulating autophagy mediated by the AMPK/mTOR signaling pathway. Histol Histopathol. 2024 Mar 27:18739. doi: 10.14670/HH-18-739. Epub ahead of print. PMID: 38606875. 16: Cipollone MA, Fontana A, Fillería SG, Tironi VA. Characterization, Bioaccesibility and Antioxidant Activities of Phenolic Compounds Recovered from Yellow pea (Pisum sativum) Flour and Protein Isolate. Plant Foods Hum Nutr. 2024 Jun;79(2):401-409. doi: 10.1007/s11130-024-01172-z. Epub 2024 Apr 11. PMID: 38602652. 17: Prasad R, Kadam A, Padippurackal VV, Pulikuttymadom Balasubramanian A, Kumar Chandrakumaran N, Suresh Rangari K, Dnyaneshwar Khangar P, Ajith H, Natarajan K, Chandramohanadas R, Nelson-Sathi S. Discovery of small molecule entry inhibitors targeting the linoleic acid binding pocket of SARS-CoV-2 spike protein. J Biomol Struct Dyn. 2024 Mar 23:1-15. doi: 10.1080/07391102.2024.2327537. Epub ahead of print. PMID: 38520147. 18: Xu Z, Hileuskaya K, Kraskouski A, Yang Y, Huang Z, Zhao Z. Inhibition of α-glucosidase activity and intestinal glucose transport to assess the in vivo anti-hyperglycemic potential of dodecyl-acylated phlorizin and polydatin derivatives. Food Funct. 2024 May 7;15(9):4785-4804. doi: 10.1039/d3fo05233h. PMID: 38511466.