JAK3i is a selective covalent inhibitor of JAK3 kinase activity. It reveals two distinct temporal waves of STAT5 phosphorylation and more potently targets the second wave, which is required for cell cycle progression and T cell proliferation.
MedKoo Cat#: 561555
Name: JAK3i
CAS#: 1918238-72-8
Chemical Formula: C18H15FN4O3
Exact Mass: 354.1128
Molecular Weight: 354.34
Elemental Analysis: C, 61.01; H, 4.27; F, 5.36; N, 15.81; O, 13.55
The following data is based on the product molecular weight 354.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
