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MedKoo Cat#: 326739 | Name: Dynasore
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dynasore is a dynamin inhibitor (IC50 = 15 μM). Dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts. Dynasore disrupts trafficking of herpes simplex virus proteins. Dynasore enhances the formation of mitochondrial antiviral signalling aggregates and endocytosis-independent NF-κB activation. Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. Dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages.

Chemical Structure

Dynasore
Dynasore
CAS#304448-55-3

Theoretical Analysis

MedKoo Cat#: 326739

Name: Dynasore

CAS#: 304448-55-3

Chemical Formula: C18H14N2O4

Exact Mass: 322.0954

Molecular Weight: 322.32

Elemental Analysis: C, 67.08; H, 4.38; N, 8.69; O, 19.85

Price and Availability

Size Price Availability Quantity
100mg USD 650.00 2 Weeks
200mg USD 950.00 2 Weeks
500mg USD 1,650.00 2 Weeks
1g USD 2,650.00 2 Weeks
2g USD 3,950.00 2 Weeks
5g USD 6,250.00 2 Weeks
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Synonym
Dynasore;
IUPAC/Chemical Name
(E)-N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide
InChi Key
SYNDQCRDGGCQRZ-VXLYETTFSA-N
InChi Code
InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
SMILES Code
OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=CC(O)=C(O)C=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Dynasore is a cell-permeable Dynamin inhibitor with an IC50 of 15 μM.
In vitro activity:
Dynasore inhibited HSV-1 and HSV-2 infection of human epithelial and neuronal cells, including primary genital tract cells and human fetal neurons and astrocytes. Reference: J Virol. 2015 Jul;89(13):6673-84. https://pubmed.ncbi.nlm.nih.gov/25878109/
In vivo activity:
Results of motor functional test indicated that dynasore ameliorated the motor dysfunction greatly at 3, 7, and 10 days after SCI in rats (P < 0.05). To this study’s knowledge, this is the first study to indicate that dynasore significantly enhances motor function which may be by inhibiting the activation of neuronal mitochondrial apoptotic pathway and astrocytic proliferation in rats after SCI. Reference: Mol Neurobiol. 2017 Nov;54(9):7471-7482. https://pubmed.ncbi.nlm.nih.gov/27822712/
Solvent mg/mL mM
Solubility
DMF 25.0 77.56
DMF:PBS (pH 7.2) (1:1) 0.5 1.55
DMSO 39.7 123.12
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 322.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Mues MB, Cheshenko N, Wilson DW, Gunther-Cummins L, Herold BC. Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol. 2015 Jul;89(13):6673-84. doi: 10.1128/JVI.00636-15. Epub 2015 Apr 15. PMID: 25878109; PMCID: PMC4468502. 2. Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006 Jun;10(6):839-50. doi: 10.1016/j.devcel.2006.04.002. PMID: 16740485. 3. Li G, Shen F, Fan Z, Wang Y, Kong X, Yu D, Zhi X, Lv G, Cao Y. Dynasore Improves Motor Function Recovery via Inhibition of Neuronal Apoptosis and Astrocytic Proliferation after Spinal Cord Injury in Rats. Mol Neurobiol. 2017 Nov;54(9):7471-7482. doi: 10.1007/s12035-016-0252-1. Epub 2016 Nov 7. PMID: 27822712. 4. Gao D, Zhang L, Dhillon R, Hong TT, Shaw RM, Zhu J. Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS One. 2013 Apr 15;8(4):e60967. doi: 10.1371/journal.pone.0060967. PMID: 23596510; PMCID: PMC3626591.
In vitro protocol:
1. Mues MB, Cheshenko N, Wilson DW, Gunther-Cummins L, Herold BC. Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol. 2015 Jul;89(13):6673-84. doi: 10.1128/JVI.00636-15. Epub 2015 Apr 15. PMID: 25878109; PMCID: PMC4468502. 2. Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006 Jun;10(6):839-50. doi: 10.1016/j.devcel.2006.04.002. PMID: 16740485.
In vivo protocol:
1. Li G, Shen F, Fan Z, Wang Y, Kong X, Yu D, Zhi X, Lv G, Cao Y. Dynasore Improves Motor Function Recovery via Inhibition of Neuronal Apoptosis and Astrocytic Proliferation after Spinal Cord Injury in Rats. Mol Neurobiol. 2017 Nov;54(9):7471-7482. doi: 10.1007/s12035-016-0252-1. Epub 2016 Nov 7. PMID: 27822712. 2. Gao D, Zhang L, Dhillon R, Hong TT, Shaw RM, Zhu J. Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS One. 2013 Apr 15;8(4):e60967. doi: 10.1371/journal.pone.0060967. PMID: 23596510; PMCID: PMC3626591.
1: Thirukonda GJ, Uehara S, Nakayama T, Yamashita T, Nakamura Y, Mizoguchi T, Takahashi N, Yagami K, Udagawa N, Kobayashi Y. The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts. J Bone Miner Metab. 2016 Jul;34(4):395-405. doi: 10.1007/s00774-015-0683-1. Epub 2015 Jun 11. PubMed PMID: 26063501. 2: Preta G, Cronin JG, Sheldon IM. Dynasore - not just a dynamin inhibitor. Cell Commun Signal. 2015 Apr 10;13:24. doi: 10.1186/s12964-015-0102-1. Review. PubMed PMID: 25889964; PubMed Central PMCID: PMC4396812. 3: Mues MB, Cheshenko N, Wilson DW, Gunther-Cummins L, Herold BC. Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol. 2015 Jul;89(13):6673-84. doi: 10.1128/JVI.00636-15. Epub 2015 Apr 15. PubMed PMID: 25878109; PubMed Central PMCID: PMC4468502. 4: Ailenberg M, Di Ciano-Oliveira C, Szaszi K, Dan Q, Rozycki M, Kapus A, Rotstein OD. Dynasore enhances the formation of mitochondrial antiviral signalling aggregates and endocytosis-independent NF-κB activation. Br J Pharmacol. 2015 Aug;172(15):3748-63. doi: 10.1111/bph.13162. Epub 2015 May 15. PubMed PMID: 25850711; PubMed Central PMCID: PMC4523333. 5: Malomouzh AI, Mukhitov AR, Proskurina SE, Vyskocil F, Nikolsky EE. The effect of dynasore, a blocker of dynamin-dependent endocytosis, on spontaneous quantal and non-quantal release of acetylcholine in murine neuromuscular junctions. Dokl Biol Sci. 2014 Nov;459:330-3. doi: 10.1134/S0012496614060052. Epub 2015 Jan 6. PubMed PMID: 25560208. 6: Preta G, Lotti V, Cronin JG, Sheldon IM. Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes. FASEB J. 2015 Apr;29(4):1516-28. doi: 10.1096/fj.14-265207. Epub 2014 Dec 30. PubMed PMID: 25550455; PubMed Central PMCID: PMC4396600. 7: Wang QC, Liu J, Duan X, Cui XS, Kim NH, Xiong B, Sun SC. The Dynamin 2 inhibitor Dynasore affects the actin filament distribution during mouse early embryo development. J Reprod Dev. 2015;61(1):49-53. doi: 10.1262/jrd.2014-079. Epub 2014 Nov 21. PubMed PMID: 25421092; PubMed Central PMCID: PMC4354231. 8: Lum M, Attridge SR, Morona R. Impact of dynasore an inhibitor of dynamin II on Shigella flexneri infection. PLoS One. 2013 Dec 19;8(12):e84975. doi: 10.1371/journal.pone.0084975. eCollection 2013. PubMed PMID: 24367704; PubMed Central PMCID: PMC3868620. 9: McCluskey A, Daniel JA, Hadzic G, Chau N, Clayton EL, Mariana A, Whiting A, Gorgani NN, Lloyd J, Quan A, Moshkanbaryans L, Krishnan S, Perera S, Chircop M, von Kleist L, McGeachie AB, Howes MT, Parton RG, Campbell M, Sakoff JA, Wang X, Sun JY, Robertson MJ, Deane FM, Nguyen TH, Meunier FA, Cousin MA, Robinson PJ. Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic. 2013 Dec;14(12):1272-89. doi: 10.1111/tra.12119. Epub 2013 Oct 9. PubMed PMID: 24025110; PubMed Central PMCID: PMC4138991. 10: Gao D, Zhang L, Dhillon R, Hong TT, Shaw RM, Zhu J. Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS One. 2013 Apr 15;8(4):e60967. doi: 10.1371/journal.pone.0060967. Print 2013. PubMed PMID: 23596510; PubMed Central PMCID: PMC3626591. 11: Girard E, Paul JL, Fournier N, Beaune P, Johannes L, Lamaze C, Védie B. The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages. PLoS One. 2011;6(12):e29042. doi: 10.1371/journal.pone.0029042. Epub 2011 Dec 19. PubMed PMID: 22205993; PubMed Central PMCID: PMC3242776. 12: Seil M, El Ouaaliti M, Dehaye JP. Secretion of IL-1β triggered by dynasore in murine peritoneal macrophages. Innate Immun. 2012 Apr;18(2):241-9. doi: 10.1177/1753425911399478. Epub 2011 Jun 27. PubMed PMID: 21709053. 13: Douthitt HL, Luo F, McCann SD, Meriney SD. Dynasore, an inhibitor of dynamin, increases the probability of transmitter release. Neuroscience. 2011 Jan 13;172:187-95. doi: 10.1016/j.neuroscience.2010.10.002. Epub 2010 Nov 5. PubMed PMID: 21056636. 14: Barrias ES, Reignault LC, De Souza W, Carvalho TM. Dynasore, a dynamin inhibitor, inhibits Trypanosoma cruzi entry into peritoneal macrophages. PLoS One. 2010 Jan 20;5(1):e7764. doi: 10.1371/journal.pone.0007764. PubMed PMID: 20098746; PubMed Central PMCID: PMC2808331. 15: Yamada H, Abe T, Li SA, Masuoka Y, Isoda M, Watanabe M, Nasu Y, Kumon H, Asai A, Takei K. Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1142-8. doi: 10.1016/j.bbrc.2009.10.105. Epub 2009 Oct 24. PubMed PMID: 19857461. 16: Tsai CC, Lin CL, Wang TL, Chou AC, Chou MY, Lee CH, Peng IW, Liao JH, Chen YT, Pan CY. Dynasore inhibits rapid endocytosis in bovine chromaffin cells. Am J Physiol Cell Physiol. 2009 Aug;297(2):C397-406. doi: 10.1152/ajpcell.00562.2008. Epub 2009 Jun 10. PubMed PMID: 19515902. 17: Young A, Gentzsch M, Abban CY, Jia Y, Meneses PI, Bridges RJ, Bradbury NA. Dynasore inhibits removal of wild-type and DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) from the plasma membrane. Biochem J. 2009 Jul 15;421(3):377-85. doi: 10.1042/BJ20090389. PubMed PMID: 19442237. 18: Chung CL, Sheu JR, Liu HE, Chang SC, Chou YC, Chen WL, Chou DS, Hsiao G. Dynasore, a dynamin inhibitor, induces PAI-1 expression in MeT-5A human pleural mesothelial cells. Am J Respir Cell Mol Biol. 2009 Jun;40(6):692-700. doi: 10.1165/rcmb.2008-0087OC. Epub 2008 Oct 31. PubMed PMID: 18978303. 19: Abban CY, Bradbury NA, Meneses PI. HPV16 and BPV1 infection can be blocked by the dynamin inhibitor dynasore. Am J Ther. 2008 Jul-Aug;15(4):304-11. doi: 10.1097/MJT.0b013e3181754134. PubMed PMID: 18645330; PubMed Central PMCID: PMC2519006. 20: Kirchhausen T, Macia E, Pelish HE. Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods Enzymol. 2008;438:77-93. doi: 10.1016/S0076-6879(07)38006-3. PubMed PMID: 18413242; PubMed Central PMCID: PMC2796620.