Quadrosilan | CAS#4657-20-9

MedKoo Cat#: 206925 | Name: Quadrosilan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Quadrosilan, also known as Cisobitan and KABI-1774, is a synthetic, nonsteroidal estrogen that was developed in the 1970s and that is or has been used as an antigonadotropic agent in the treatment of prostate cancer. It is an organosilicon compound, and is also known as 2,6-cisdiphenylhexamethylcyclotetrasiloxane. Quadrosilan has estrogenic activity equivalent to that of estradiol, and can produce feminization and gynecomastia as side effects in male patients.

Chemical Structure

Quadrosilan

CAS#4657-20-9

Theoretical Analysis

MedKoo Cat#: 206925

Name: Quadrosilan

CAS#: 4657-20-9

Chemical Formula: C18H28O4Si4

Exact Mass: 420.1065

Molecular Weight: 420.76

Elemental Analysis: C, 51.38; H, 6.71; O, 15.21; Si, 26.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Quadrosilan, Cisobitan; KABI-1774; KABI 1774; KABI1774.

IUPAC/Chemical Name

2,2,4,6,6,8-hexamethyl-4,8-diphenyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane

InChi Key

ZTQZMPQJXABFNC-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H28O4Si4/c1-23(2)19-25(5,17-13-9-7-10-14-17)21-24(3,4)22-26(6,20-23)18-15-11-8-12-16-18/h7-16H,1-6H3

SMILES Code

C[Si]1(C2=CC=CC=C2)O[Si](C)(C)O[Si](C3=CC=CC=C3)(C)O[Si](C)(C)O1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 420.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Alfthan O, Andersson L, Esposti PL, Fosså SD, Gammelgaard PA, Gjöres JE, Isacson S, Rasmussen F, Ruutu M, von Schreeb T, Setterberg G, Strandell P, Strindberg B. Cisobitan in treatment of prostatic cancer. A prospective controlled multicentre study. Scand J Urol Nephrol. 1983;17(1):37-43. PubMed PMID: 6346476. 2: Collste L, Berlin T, von Garrelts B, Granberg I, Lewander R. Clinical trial of a new antigonadotropic substance, 2,6-cis-diphenylhexamethylcyclotetrasiloxane, in cancer of the prostate. A pilot study. Eur Urol. 1981;7(2):85-8. PubMed PMID: 7461008. 3: Sundwall A. Cisobitan--a new drug with anti-gonadotropic and anti-androgenic properties. Pharmacological effects. Scand J Urol Nephrol Suppl. 1980;55:121-5. PubMed PMID: 6938014. 4: Albanus L, Björklund NE, Gustafsson B, Jönsson M. Forty days oral toxicity of 2,6-cis-diphenylhexamethylcyclotetrasiloxane (KABI 1774)in beagle dogs with special reference to effects on the male reproductive system. Acta Pharmacol Toxicol (Copenh). 1975;36(Suppl 3):93-130. PubMed PMID: 1080338. 5: Nicander L. Changes produced in the male genital organs of rabbits and dogs by 2,6-cis-diphenylhexamethylcyclotetrasiloxane (KABI 1774). Acta Pharmacol Toxicol (Copenh). 1975;36(Suppl 3):40-54. PubMed PMID: 1080333. 6: Schmiterlöw CG, Sjögren C. The distribution of 14-C labelled KABI 1774. Acta Pharmacol Toxicol (Copenh). 1975;36(Suppl 3):131-8. PubMed PMID: 1080328. 7: Nicander L. The effects on the male genital organs and dogs of a new antifertility compound KABI 1774. J Reprod Fertil. 1972 Dec;31(3):517-8. PubMed PMID: 4653473.