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MedKoo Cat#: 581039 | Name: TCMTB
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TCMTB is an antimicrobial agent used as a substitute for chlorophenols in industrial applications. Biocide used in the leather, pulp and paper, and water-treatment industries.

Chemical Structure

TCMTB
TCMTB
CAS#21564-17-0

Theoretical Analysis

MedKoo Cat#: 581039

Name: TCMTB

CAS#: 21564-17-0

Chemical Formula: C9H6N2S3

Exact Mass: 237.9693

Molecular Weight: 238.34

Elemental Analysis: C, 45.35; H, 2.54; N, 11.75; S, 40.35

Price and Availability

Size Price Availability Quantity
100mg USD 350.00 2 Weeks
250mg USD 650.00 2 Weeks
500mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
TCMTB, Benthiazole, Thiocyanic acid, Acticide WB 300, Superdavloxan
IUPAC/Chemical Name
1,3-Benzothiazol-2-ylsulfanylmethyl thiocyanate
InChi Key
TUBQDCKAWGHZPF-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H6N2S3/c10-5-12-6-13-9-11-7-3-1-2-4-8(7)14-9/h1-4H,6H2
SMILES Code
N#CSCSC1=NC2=CC=CC=C2S1
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 238.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhao T, Zhang Y, Liu L, Deng X, Guo J, Cao S, Zhu D, Xu J, Nikolaevna UV, Maratbek S, Wang Z, Sun Z, Gu X, Zhang H. Systemic Pharmacology Reveals the Potential Targets and Signaling Mechanisms in the Adjuvant Treatment of Brucellosis with Traditional Chinese Medicine. ACS Omega. 2023 Jul 28;8(31):28797-28812. doi: 10.1021/acsomega.3c03716. PMID: 37576692; PMCID: PMC10413447. 2: Herman A, Marot L, Baeck M. Sofa dermatitis: Value of patch test with 2-(thiocyanomethylthio)benzothiazole. Contact Dermatitis. 2023 Jul;89(1):20-25. doi: 10.1111/cod.14320. Epub 2023 Apr 10. PMID: 37037196. 3: Mardani Z, Shakoori A, Peiravian F, Nouri L, Salamzadeh J. Development of A Liquid Chromatography-Mass Spectrometry Technique for Evaluation of Multi-class Pesticides in Rice Samples. Iran J Pharm Res. 2021 Winter;20(1):165-174. doi: 10.22037/ijpr.2020.113071.14095. PMID: 34400950; PMCID: PMC8170775. 4: Bertoldi C, de Cássia Campos Pena A, Dallegrave A, Fernandes AN, Gutterres M. Photodegradation of Emerging Contaminant 2-(tiocyanomethylthio) Benzothiazole (TCMTB) in Aqueous Solution: Kinetics and Transformation Products. Bull Environ Contam Toxicol. 2020 Sep;105(3):433-439. doi: 10.1007/s00128-020-02954-2. Epub 2020 Aug 1. PMID: 32740745. 5: Herman A, Goossens A, Tennstedt D, Bergendorff O, Isaksson M, Mowitz M, Baeck M. The preservative 2-(thiocyanomethylthio)benzothiazole: A potential allergen in leather products. Contact Dermatitis. 2019 Oct;81(4):262-265. doi: 10.1111/cod.13295. Epub 2019 May 31. PMID: 31006870. 6: Shin N, Cuenca L, Karthikraj R, Kannan K, Colaiácovo MP. Assessing effects of germline exposure to environmental toxicants by high-throughput screening in C. elegans. PLoS Genet. 2019 Feb 14;15(2):e1007975. doi: 10.1371/journal.pgen.1007975. PMID: 30763314; PMCID: PMC6375566. 7: Kavitha S, Khambhaty Y, Chandra Babu NK. Evaluation of Industrial Biocides on a Novel Aspergillus versicolor TANCK-1 and Elucidation of Their Probable Biocidal Mechanism. Indian J Microbiol. 2018 Mar;58(1):51-59. doi: 10.1007/s12088-017-0696-7. Epub 2017 Dec 9. PMID: 29434397; PMCID: PMC5801185. 8: Caldas SS, Soares BM, Abreu F, Castro ÍB, Fillmann G, Primel EG. Antifouling booster biocide extraction from marine sediments: a fast and simple method based on vortex-assisted matrix solid-phase extraction. Environ Sci Pollut Res Int. 2018 Mar;25(8):7553-7565. doi: 10.1007/s11356-017-0942-x. Epub 2017 Dec 27. PMID: 29282665. 9: Martins SE, Fillmann G, Lillicrap A, Thomas KV. Review: ecotoxicity of organic and organo-metallic antifouling co-biocides and implications for environmental hazard and risk assessments in aquatic ecosystems. Biofouling. 2018 Jan;34(1):34-52. doi: 10.1080/08927014.2017.1404036. Epub 2017 Dec 17. PMID: 29250978. 10: Batista-Andrade JA, Caldas SS, Batista RM, Castro IB, Fillmann G, Primel EG. From TBT to booster biocides: Levels and impacts of antifouling along coastal areas of Panama. Environ Pollut. 2018 Mar;234:243-252. doi: 10.1016/j.envpol.2017.11.063. Epub 2017 Nov 24. PMID: 29179127. 11: Lee S, Lee D, Lee YW. Determination of Five Alternative Antifouling Agents Found Along the Korean Coasts. Water Environ Res. 2017 Jul 1;89(7):622-628. doi: 10.2175/106143017X14902968254511. PMID: 28641672. 12: Batista-Andrade JA, Caldas SS, de Oliveira Arias JL, Castro IB, Fillmann G, Primel EG. Antifouling booster biocides in coastal waters of Panama: First appraisal in one of the busiest shipping zones. Mar Pollut Bull. 2016 Nov 15;112(1-2):415-419. doi: 10.1016/j.marpolbul.2016.07.045. Epub 2016 Aug 2. PMID: 27496683. 13: Shakouri A, Yazdanpanah H, Shojaee MH, Kobarfard F. Method Development for Simultaneous Determination of 41 Pesticides in Rice Using LC-MS/MS Technique and Its Application for the Analysis of 60 Rice Samples Collected from Tehran Market. Iran J Pharm Res. 2014 Summer;13(3):927-35. PMID: 25276193; PMCID: PMC4177653. 14: Giráldez I, Chaguaceda E, Bujalance M, Morales E. Determination of five booster biocides in seawater by stir bar sorptive extraction-thermal desorption- gas chromatography-mass spectrometry. J Chromatogr A. 2013 Jan 4;1271(1):17-26. doi: 10.1016/j.chroma.2012.11.017. Epub 2012 Nov 19. PMID: 23246091. 15: Vyhnalkova R, Eisenberg A, van de Ven TG. Deactivation efficiency of stabilized bactericidal emulsions. Langmuir. 2011 Sep 20;27(18):11296-305. doi: 10.1021/la201112j. Epub 2011 Aug 22. PMID: 21823610. 16: Sánchez-Rodríguez A, Sosa-Ferrera Z, Santana-del Pino A, Santana-Rodríguez JJ. Probabilistic risk assessment of common booster biocides in surface waters of the harbours of Gran Canaria (Spain). Mar Pollut Bull. 2011 May;62(5):985-91. doi: 10.1016/j.marpolbul.2011.02.038. Epub 2011 Mar 10. PMID: 21396664. 17: Vyhnalkova R, Eisenberg A, van de Ven T. Bactericidal block copolymer micelles. Macromol Biosci. 2011 May 12;11(5):639-51. doi: 10.1002/mabi.201000428. Epub 2011 Jan 27. PMID: 21275041. 18: Sánchez-Rodríguez A, Sosa-Ferrera Z, Santana-Rodríguez JJ. Applicability of microwave-assisted extraction combined with LC-MS/MS in the evaluation of booster biocide levels in harbour sediments. Chemosphere. 2011 Jan;82(1):96-102. doi: 10.1016/j.chemosphere.2010.09.064. Epub 2010 Oct 13. PMID: 20947123. 19: Muñoz I, Martínez Bueno MJ, Agüera A, Fernández-Alba AR. Environmental and human health risk assessment of organic micro-pollutants occurring in a Spanish marine fish farm. Environ Pollut. 2010 May;158(5):1809-16. doi: 10.1016/j.envpol.2009.11.006. Epub 2009 Nov 22. PMID: 19932535. 20: Martínez Bueno MJ, Hernando MD, Agüera A, Fernández-Alba AR. Application of passive sampling devices for screening of micro-pollutants in marine aquaculture using LC-MS/MS. Talanta. 2009 Feb 15;77(4):1518-27. doi: 10.1016/j.talanta.2008.09.047. Epub 2008 Oct 9. PMID: 19084673.

View History

TCMDC-135051

TCMDC-135051