Synonym
Necrostatin-2; (±)-Necrostatin-2; 7-Cl-O-Nec-1; Nec-1s;
IUPAC/Chemical Name
5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione
InChi Key
WIKGAEMMNQTUGL-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)
SMILES Code
O=C1N(C)C(C(CC2=CNC3=C2C=CC=C3Cl)N1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
277.71
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wang Q, Zhou T, Liu Z, Ren J, Phan N, Gupta K, Stewart DM, Morgan S, Assa C,
Kent KC, Liu B. Inhibition of Receptor-Interacting Protein Kinase 1 with
Necrostatin-1s ameliorates disease progression in elastase-induced mouse
abdominal aortic aneurysm model. Sci Rep. 2017 Feb 10;7:42159. doi:
10.1038/srep42159. PubMed PMID: 28186202; PubMed Central PMCID: PMC5301478.
2: Huang Z, Epperly M, Watkins SC, Greenberger JS, Kagan VE, Bayır H.
Necrostatin-1 rescues mice from lethal irradiation. Biochim Biophys Acta. 2016
Apr;1862(4):850-856. doi: 10.1016/j.bbadis.2016.01.014. Epub 2016 Jan 20. PubMed
PMID: 26802452; PubMed Central PMCID: PMC4788560.
3: Berger SB, Harris P, Nagilla R, Kasparcova V, Hoffman S, Swift B, Dare L,
Schaeffer M, Capriotti C, Ouellette M, King BW, Wisnoski D, Cox J, Reilly M,
Marquis RW, Bertin J, Gough PJ. Characterization of GSK'963: a structurally
distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015
Jul 27;1:15009. doi: 10.1038/cddiscovery.2015.9. eCollection 2015. PubMed PMID:
27551444; PubMed Central PMCID: PMC4979471.
-Necrostatin-24419.jpg "(±)-Necrostatin-2")
