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MedKoo Cat#: 329869 | Name: Synephrine HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Synephrine, or, more specifically, p-synephrine, is an alkaloid, occurring naturally in some plants and animals, and also in approved drugs products as its m-substituted analog known as neo-synephrine. p-Synephrine and m-synephrine are known for their longer acting adrenergic effects compared to norepinephrine. This substance is present at very low concentrations in common foodstuffs such as orange juice and other orange (Citrus species) products, both of the "sweet" and "bitter" variety.

Chemical Structure

Synephrine HCl
Synephrine HCl
CAS#5985-28-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 329869

Name: Synephrine HCl

CAS#: 5985-28-4 (HCl)

Chemical Formula: C9H14ClNO2

Exact Mass: 203.0713

Molecular Weight: 203.67

Elemental Analysis: C, 53.08; H, 6.93; Cl, 17.41; N, 6.88; O, 15.71

Price and Availability

Size Price Availability Quantity
5g USD 225.00
10g USD 370.00
25g USD 575.00
50g USD 750.00
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Related CAS #
5985-28-4 (HCl) 16589-24-5 (tartrate) 94-07-5 (racemate) 614-35-7 (R-isomer)
Synonym
Synephrine HCl; Sympatol; oxedrine;
IUPAC/Chemical Name
4-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol hydrochloride
InChi Key
COTCEGYSNTWJQV-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H
SMILES Code
CNCC(O)C1=CC=C(O)C=C1.[H]Cl
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
The preparations used in traditional Chinese medicine (TCM), also known as Zhi Shi, are the immature and dried whole oranges from Citrus aurantium (Fructus Aurantii Immaturus). Extracts of the same material or purified synephrine are also marketed in the US, sometimes in combination with caffeine, as a weight-loss-promoting dietary supplement for oral consumption. While the traditional preparations have been in use for millennia as a component of TCM-formulas, synephrine itself is not an approved OTC drug. As a pharmaceutical, m-synephrine is still used as a sympathomimetic (i.e. for its hypertensive and vasoconstrictor properties), mostly by injection for the treatment of emergencies such as shock, and rarely orally for the treatment of bronchial problems associated with asthma and hay-fever.

Preparing Stock Solutions

The following data is based on the product molecular weight 203.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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