MedKoo Cat#: 571346 | Name: Fenleuton

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fenleuton is a 5-lipoxygenase inhibitor that may be used as a bronchodilator. It could be a mediators in the treatment of COPD, particularly in equine COPD as has been investigated.

Chemical Structure

Fenleuton
Fenleuton
CAS#141579-54-6

Theoretical Analysis

MedKoo Cat#: 571346

Name: Fenleuton

CAS#: 141579-54-6

Chemical Formula: C17H15FN2O3

Exact Mass: 314.1067

Molecular Weight: 314.32

Elemental Analysis: C, 64.96; H, 4.81; F, 6.04; N, 8.91; O, 15.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Fenleuton; A-76745; A 767456; A76745
IUPAC/Chemical Name
(S)-1-(4-(3-(4-fluorophenoxy)phenyl)but-3-yn-2-yl)-1-hydroxyurea
InChi Key
MWXPQCKCKPYBDR-LBPRGKRZSA-N
InChi Code
InChI=1S/C17H15FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-4,7-12,22H,1H3,(H2,19,21)/t12-/m0/s1
SMILES Code
O=C(N)N([C@H](C#CC1=CC=CC(OC2=CC=C(F)C=C2)=C1)C)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 314.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Marr KA, Lees P, Page CP, Cunningham FM. Effect of the 5-lipoxygenase inhibitor, fenleuton, on antigen-induced neutrophil accumulation and lung function changes in horses with chronic obstructive pulmonary disease. J Vet Pharmacol Ther. 1998 Jun;21(3):241-6. PubMed PMID: 9673966. 2: Marr K, Marsh K, Hernandez L, Cunningham FM, Lees P. Pharmacokinetics and pharmacodynamics of fenleuton, a 5-lipoxygenase inhibitor, in ponies. Res Vet Sci. 1998 Mar-Apr;64(2):111-7. PubMed PMID: 9625466. 3: Rittmannsberger A, Likussar W, Michelitsch A. Development of an enzyme-modified carbon paste electrode for determining inhibitors of lipoxygenase. Biosens Bioelectron. 2005 Oct 15;21(4):655-60. Epub 2005 Jan 8. PubMed PMID: 16202879.