PF-06456384 | CAS#1834610-73-9 | NaV1.7 inhibitor

MedKoo Cat#: 530946 | Name: PF-06456384

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-06456384 is a highly potent and selective NaV1.7 inhibitor (IC50 NaV1.7 = 0.01 nM). PF-06456384 ultimately showed a lack of preclinical efficacy in a mouse formalin pain model and was not progressed further. PF-06456384 may be used to illustrate the potential to support further in vitro and in vivo evaluation of the translation of NaV1.7 inhibition to the treatment of pain.

Chemical Structure

PF-06456384

CAS#1834610-73-9 (free base)

Theoretical Analysis

MedKoo Cat#: 530946

Name: PF-06456384

CAS#: 1834610-73-9 (free base)

Chemical Formula: C35H32F3N7O3S2

Exact Mass: 719.1960

Molecular Weight: 719.80

Elemental Analysis: C, 58.40; H, 4.48; F, 7.92; N, 13.62; O, 6.67; S, 8.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1834610-73-9 (free base) 1834610-75-1 (3HCl)

Synonym

PF-06456384; PF 06456384; PF06456384; PF-6456384; PF 6456384; PF6456384.

IUPAC/Chemical Name

3-cyano-4-((3-(2-(((2-(piperidin-4-yl)ethyl)amino)methyl)pyridin-4-yl)-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)oxy)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

InChi Key

WSPHMGORSRQULF-UHFFFAOYSA-N

InChi Code

InChI=1S/C35H32F3N7O3S2/c36-35(37,38)28-3-1-2-24(16-28)25-4-6-33(48-32-7-5-30(18-27(32)20-39)50(46,47)45-34-43-22-44-49-34)31(19-25)26-11-15-42-29(17-26)21-41-14-10-23-8-12-40-13-9-23/h1-7,11,15-19,22-23,40-41H,8-10,12-14,21H2,(H,43,44,45)

SMILES Code

O=S(C(C=C1)=CC(C#N)=C1OC(C=CC(C2=CC=CC(C(F)(F)F)=C2)=C3)=C3C4=CC=NC(CNCCC5CCNCC5)=C4)(NC6=NC=NS6)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 719.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes In Press, Accepted Manuscript, Available online 28 September 2017 R. Ian Storer, Andy Pike, Nigel A. Swain, Aristos J Alexandrou, Bruce M. Bechle, David C. Blakemore, Alan D. Brown, Neil A. Castle, Matthew S. Corbett, Neil J. Flanagan, David Fengas, M. Scott Johnson, Lyn H. Jones, Brian E. Marron, C. Elizabeth Payne, David Printzenhoff, David J. Rawson, Colin R. Rose, Thomas Ryckmans, Jianmin Sun, Jonathan W Theile, et al.