NAAD sodium salt | CAS#104809-30-5 | Ca2+ release initiator

MedKoo Cat#: 561492 | Name: NAAD sodium salt

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NAAD sodium salt initiates intracellular Ca2+ release by a cyclic ADP ribose-independent and IP3 mechanism. It is also used as a substrate to study the specificity and kinetics of nicotinamide adenine dinucleotide synthetase(s) (NADS).

Chemical Structure

NAAD sodium salt

CAS#104809-30-5 (sodium)

Theoretical Analysis

MedKoo Cat#: 561492

Name: NAAD sodium salt

CAS#: 104809-30-5 (sodium)

Chemical Formula: C21H25N6NaO15P2

Exact Mass:

Molecular Weight: 686.39

Elemental Analysis: C, 36.75; H, 3.67; N, 12.24; Na, 3.35; O, 34.96; P, 9.03

Price and Availability

Size	Price	Availability	Quantity
25mg	USD 385.00	2 Weeks
100mg	USD 885.00	2 Weeks

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Related CAS #

6450-77-7 (free) 104809-30-5 (sodium)

Synonym

NAAD sodium salt; NAAD Na salt; NAAD Na, NaAD; Deamido Nad Sodium Salt; Nicotinic acid adenine dinucleotide sodium salt;

IUPAC/Chemical Name

Sodium;[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3S,4R,5R)-5-(3-carboxypyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate

InChi Key

LFHLUTZTSGEADU-RHANTIMGSA-M

InChi Code

InChI=1S/C21H26N6O15P2.Na/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(31)14(29)11(41-20)6-39-44(36,37)42-43(34,35)38-5-10-13(28)15(30)19(40-10)26-3-1-2-9(4-26)21(32)33;/h1-4,7-8,10-11,13-16,19-20,28-31H,5-6H2,(H4-,22,23,24,32,33,34,35,36,37);/q;+1/p-1/t10-,11-,13-,14-,15-,16-,19-,20-;/m1./s1

SMILES Code

O=P(OP([O-])(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O)=O)([O-])OC[C@H]4O[C@@H]([N+]5=CC=CC(C(O)=O)=C5)[C@H](O)[C@@H]4O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 686.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Elzainy TA, Ali TH. NAD deamidation "a new reaction" by an enzyme from Aspergillus terreus DSM 826. Antonie Van Leeuwenhoek. 2005 Feb;87(2):119-29. PubMed PMID: 15793621. 2: Patel S, Churchill GC, Galione A. Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand. Biochem J. 2000 Dec 15;352 Pt 3:725-9. PubMed PMID: 11104679; PubMed Central PMCID: PMC1221510.