Synonym
BIBS-222; BIBS 222; BIBS222;
IUPAC/Chemical Name
2-((4-((2-butyl-6-(3-methyl-1-pentylureido)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)carbamoyl)-3,6-dichlorobenzoic acid
InChi Key
ZHWGRXBJGUEATA-UHFFFAOYSA-N
InChi Code
InChI=1S/C33H37Cl2N5O4/c1-4-6-8-18-39(33(44)36-3)23-14-17-26-27(19-23)40(28(38-26)9-7-5-2)20-21-10-12-22(13-11-21)37-31(41)29-24(34)15-16-25(35)30(29)32(42)43/h10-17,19H,4-9,18,20H2,1-3H3,(H,36,44)(H,37,41)(H,42,43)
SMILES Code
CCCCCN(C(NC)=O)C1=CC(N(CC2=CC=C(NC(C3=C(Cl)C=CC(Cl)=C3C(O)=O)=O)C=C2)C(CCCC)=N4)=C4C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
638.60
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zhang J, Pfaffendorf M, van Zwieten PA. Hemodynamic effects of angiotensin II and the influence of angiotensin receptor antagonists in pithed rabbits. J Cardiovasc Pharmacol. 1995 May;25(5):724-31. PubMed PMID: 7630151.
2: Zhang J, Pfaffendorf M, van Zwieten PA. Effect of various angiotensin receptor antagonists on cardiovascular responses to angiotensin II in pithed rats. J Cardiovasc Pharmacol. 1994 Jul;24(1):108-13. PubMed PMID: 7521474.
3: Zhang JS, Van Meel JC, Pfaffendorf M, Van Zwieten PA. Different types of angiotensin II receptor antagonism induced by BIBS 222 in the rat portal vein and rabbit aorta; the influence of receptor reserve. J Pharmacol Exp Ther. 1994 May;269(2):509-14. PubMed PMID: 8182519.
4: Zhang JS, van Meel JC, Pfaffendorf M, van Zwieten PA. Inhibitory effect of dithiothreitol on angiotensin II-induced contractions mediated by AT1-receptors in rat portal vein and rabbit aorta. Naunyn Schmiedebergs Arch Pharmacol. 1994 May;349(5):538-42. PubMed PMID: 8065468.
5: Zhang J, Van Meel JC, Van Zwieten PA. Antihypertensive activity of the novel, nonpeptide angiotensin II receptor antagonists BIBS 39 and BIBS 222 in conscious renal hypertensive rats. Pharmacology. 1993 May;46(5):241-7. PubMed PMID: 8488169.
6: van Meel JC, Entzeroth M, Hauel N, Narr B, Ries U, Wienen W. Angiotensin II receptor antagonists. Arzneimittelforschung. 1993 Feb;43(2A):242-6. Review. PubMed PMID: 8498971.
7: Zhang J, Entzeroth M, Wienen W, Van Meel JC. Characterization of BIBS 39 and BIBS 222: two new nonpeptide angiotensin II receptor antagonists. Eur J Pharmacol. 1992 Jul 21;218(1):35-41. PubMed PMID: 1397034.
