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MedKoo Cat#: 412964 | Name: Cistanoside A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cistanoside A is an active phenylethanoid glycoside isolated from Cistanche deserticola Y. C. Ma, has received our attention because of its possible role in the treatment of osteoporosis.

Chemical Structure

Cistanoside A
Cistanoside A
CAS#93236-42-1

Theoretical Analysis

MedKoo Cat#: 412964

Name: Cistanoside A

CAS#: 93236-42-1

Chemical Formula: C36H48O20

Exact Mass: 800.2739

Molecular Weight: 800.76

Elemental Analysis: C, 54.00; H, 6.04; O, 39.96

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 685.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Cistanoside A
IUPAC/Chemical Name
(2R,3R,4R,5R,6R)-5-hydroxy-6-(4-hydroxy-3-methoxyphenethoxy)-2-((((2R,3R,4S,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)-4-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl (E)-3-(3,4-dihydroxyphenyl)acrylate
InChi Key
LOGNFAUMIGACHZ-SCWCVTEDSA-N
InChi Code
InChI=1S/C36H48O20/c1-15-25(42)27(44)30(47)36(52-15)56-33-31(48)35(50-10-9-17-4-7-19(39)21(12-17)49-2)54-23(14-51-34-29(46)28(45)26(43)22(13-37)53-34)32(33)55-24(41)8-5-16-3-6-18(38)20(40)11-16/h3-8,11-12,15,22-23,25-40,42-48H,9-10,13-14H2,1-2H3/b8-5+/t15-,22-,23+,25-,26+,27+,28-,29+,30+,31+,32+,33+,34+,35+,36-/m0/s1
SMILES Code
O=C(O[C@@H]1[C@@H](CO[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O2)O[C@@H](OCCC3=CC=C(O)C(OC)=C3)[C@H](O)[C@H]1O[C@H]4[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4)/C=C/C5=CC=C(O)C(O)=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 800.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen T, Gao F, Luo D, Wang S, Zhao Y, Liu S, Huang J, Lin Y, Zhang Z, Huang H, Wan L. Cistanoside A promotes osteogenesis of primary osteoblasts by alleviating apoptosis and activating autophagy through involvement of the Wnt/β-catenin signal pathway. Ann Transl Med. 2022 Jan;10(2):64. doi: 10.21037/atm-21-6742. PMID: 35282110; PMCID: PMC8848445. 2: Xu X, Zhang Z, Wang W, Yao H, Ma X. Therapeutic Effect of Cistanoside A on Bone Metabolism of Ovariectomized Mice. Molecules. 2017 Jan 24;22(2):197. doi: 10.3390/molecules22020197. PMID: 28125037; PMCID: PMC6155935. 3: Xu C, Wu Y, Tang L, Liang Y, Zhao Y. Protective effect of cistanoside A on dopaminergic neurons in Parkinson's disease via mitophagy. Biotechnol Appl Biochem. 2023 Feb;70(1):268-280. doi: 10.1002/bab.2350. Epub 2022 May 5. PMID: 35420720. 4: Luo H, Cao R, Wang L, Zhu L. Protective effect of Cistanchis A on ethanol- induced damage in primary cultured mouse hepatocytes. Biomed Pharmacother. 2016 Oct;83:1071-1079. doi: 10.1016/j.biopha.2016.08.028. Epub 2016 Aug 19. PMID: 27544551. 5: Yan Y, Liu TX, Bi D, Liu WJ, Song QQ, Li J, Song YL, Tu PF, Zhao YF. [Transformation pathways in methanol of echinacoside, a principal effective ingredient of Cistanches Herba]. Zhongguo Zhong Yao Za Zhi. 2018 Jun;43(11):2321-2325. Chinese. doi: 10.19540/j.cnki.cjcmm.20180309.001. PMID: 29945385. 6: Li L, Tsao R, Yang R, Liu C, Young JC, Zhu H. Isolation and purification of phenylethanoid glycosides from Cistanche deserticola by high-speed counter- current chromatography. Food Chem. 2008 May 15;108(2):702-10. doi: 10.1016/j.foodchem.2007.10.082. Epub 2007 Nov 6. PMID: 26059151. 7: Cao ZY, Liu JT, Han YQ, Zhang TJ, Xu J. [Identification of Q-markers for Cistanches Herba based on HPLC-Q-TOF-MS/MS and network pharmacology]. Zhongguo Zhong Yao Za Zhi. 2022 Apr;47(7):1790-1801. Chinese. doi: 10.19540/j.cnki.cjcmm.20211210.201. PMID: 35534249. 8: Wang X, Wang J, Guan H, Xu R, Luo X, Su M, Chang X, Tan W, Chen J, Shi Y. Comparison of the Chemical Profiles and Antioxidant Activities of Different Parts of Cultivated Cistanche deserticola Using Ultra Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry and a 1,1-Diphenyl-2-picrylhydrazyl-Based Assay. Molecules. 2017 Nov 20;22(11):2011. doi: 10.3390/molecules22112011. PMID: 29156652; PMCID: PMC6150175. 9: Zheng S, Jiang X, Wu L, Wang Z, Huang L. Chemical and genetic discrimination of Cistanches Herba based on UPLC-QTOF/MS and DNA barcoding. PLoS One. 2014 May 22;9(5):e98061. doi: 10.1371/journal.pone.0098061. PMID: 24854031; PMCID: PMC4031141. 10: Xiong Q, Kadota S, Tani T, Namba T. Antioxidative effects of phenylethanoids from Cistanche deserticola. Biol Pharm Bull. 1996 Dec;19(12):1580-5. doi: 10.1248/bpb.19.1580. PMID: 8996643. 11: Hu GS, Hur YJ, Jia JM, Lee JH, Chung YS, Yi YB, Yun DJ, Park SK, Kim DH. Effects of 2-aminoindan-2-phosphonic acid treatment on the accumulation of salidroside and four phenylethanoid glycosides in suspension cell culture of Cistanche deserticola. Plant Cell Rep. 2011 Apr;30(4):665-74. doi: 10.1007/s00299-010-0997-3. Epub 2011 Jan 18. PMID: 21243361. 12: Zhou Y, Li W, Han LF, Song XB, Li PF, Wang R, Zhang B-. [Identification of Chinese Traditional Medicine Cistanches Herba from Different Places by HPLC-ESI- MS and FTIR Methods]. Guang Pu Xue Yu Guang Pu Fen Xi. 2015 Apr;35(4):1056-61. Japanese. PMID: 26197602. 13: Xiong Q, Tezuka Y, Kaneko T, Li H, Tran LQ, Hase K, Namba T, Kadota S. Inhibition of nitric oxide by phenylethanoids in activated macrophages. Eur J Pharmacol. 2000 Jul 14;400(1):137-44. doi: 10.1016/s0014-2999(00)00354-x. PMID: 10913595. 14: Gao Y, Guo LN, Ma SC, Liu J, Zheng J, Zan K. [Comparative studies of three Cistanche speices based on UPLC specific chromatogram and determination of main components]. Zhongguo Zhong Yao Za Zhi. 2019 Sep;44(17):3749-3757. Chinese. doi: 10.19540/j.cnki.cjcmm.20190624.201. PMID: 31602949. 15: Zhang SJ, Liu L, Zhang SY, Hu JP, Wang HJ. [A study on quality standard for herba cistanches]. Zhongguo Zhong Yao Za Zhi. 2000 Jun;25(6):359-61. Chinese. PMID: 12512425. 16: Yang JH, Hu JP, Rena K, Du NS. [Structure-activity relationships of phenylethanoid glycosides in plants of Cistanche salsa on antioxidative activity]. Zhong Yao Cai. 2009 Jul;32(7):1067-9. Chinese. PMID: 19873735. 17: Zhang M, Miao Y, Zhang X, Sun X, Li M, Huang L. Revealing ecotype influences on Cistanche sinensis: from the perspective of endophytes to metabolites characteristics. Front Microbiol. 2023 Jun 27;14:1154688. doi: 10.3389/fmicb.2023.1154688. PMID: 37538848; PMCID: PMC10394521. 18: Huang CY, Ouyang DW, Niu LX, Zhou J, Lin S, Hu X. [Study on quality evaluation of Dihuang (Rehmannia glutinosa) by two-dimension HPLC fingerprints and chemometrics methods]. Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(8):1667-1674. Chinese. doi: 10.19540/j.cnki.cjcmm.20180224.001. PMID: 29751715. 19: Wang YM, Zhang SJ, Luo GA, Hu YN, Hu JP, Liu L, Zhu Y, Wang HJ. [Analysis of phenylethanoid glycosides in the extract of herba Cistanchis by LC/ESI-MS/MS]. Yao Xue Xue Bao. 2000 Nov;35(11):839-42. Chinese. PMID: 11218862. 20: Yamada P, Iijima R, Han J, Shigemori H, Yokota S, Isoda H. Inhibitory effect of acteoside isolated from Cistanche tubulosa on chemical mediator release and inflammatory cytokine production by RBL-2H3 and KU812 cells. Planta Med. 2010 Oct;76(14):1512-8. doi: 10.1055/s-0030-1249775. Epub 2010 Mar 30. PMID: 20354949.