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MedKoo Cat#: 540300 | Name: Mivacurium chloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mivacurium chloride is a non-depolarizing NMJ blocker and nAChR antagonist used as an anesthetic. It inhibits skeletal muscle contractility and prevents atrial fibrillation.

Chemical Structure

Mivacurium chloride
Mivacurium chloride
CAS#106861-44-3 (chloride)

Theoretical Analysis

MedKoo Cat#: 540300

Name: Mivacurium chloride

CAS#: 106861-44-3 (chloride)

Chemical Formula: C58H80Cl2N2O14

Exact Mass: 0.0000

Molecular Weight: 1100.18

Elemental Analysis: C, 63.32; H, 7.33; Cl, 6.44; N, 2.55; O, 20.36

Price and Availability

Size Price Availability Quantity
10mg USD 285.00 2 weeks
25mg USD 550.00 2 weeks
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Related CAS #
106861-44-3 (chloride) 133814-19-4 (cation)
Synonym
BW-B 1090U; BWB1090U; BW B 1090 U; Mivacron; Mivacurium chloride
IUPAC/Chemical Name
(1R,1'R)-2,2'-[[(4E)-1,8-Dioxo-4-octene-1,8-diyl]bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinolinium] chloride
InChi Key
WMSYWJSZGVOIJW-ONUALHDOSA-L
InChi Code
InChI=1S/C58H80N2O14.2ClH/c1-59(25-21-41-35-47(63-3)49(65-5)37-43(41)45(59)29-39-31-51(67-7)57(71-11)52(32-39)68-8)23-17-27-73-55(61)19-15-13-14-16-20-56(62)74-28-18-24-60(2)26-22-42-36-48(64-4)50(66-6)38-44(42)46(60)30-40-33-53(69-9)58(72-12)54(34-40)70-10;;/h13-14,31-38,45-46H,15-30H2,1-12H3;2*1H/q+2;;/p-2/b14-13+;;/t45-,46-,59?,60?;;/m1../s1
SMILES Code
O=C(OCCC[N@@+]1(C)[C@H](CC2=CC(OC)=C(OC)C(OC)=C2)C3=C(C=C(OC)C(OC)=C3)CC1)CC/C=C/CCC(OCCC[N@@+]4(C)[C@H](CC5=CC(OC)=C(OC)C(OC)=C5)C6=C(C=C(OC)C(OC)=C6)CC4)=O.[Cl-].[Cl-]
Appearance
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Mivacurium chloride is a non-depolarizing NMJ blocker and nAChR antagonist.
In vitro activity:
Mivacurium induced LAD2 cell degranulation in a dose-dependent manner. Mivacurium stimulated intracellular calcium ion (Ca2+) influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells. Reference: Cell Immunol. 2018 Oct;332:121-128. https://pubmed.ncbi.nlm.nih.gov/30121125/
In vivo activity:
Changes in pulmonary inflation pressures and heart rates induced by vagal nerve stimulation and intravenous acetylcholine were measured in the absence and presence of increasing doses of gallamine, pancuronium, mivacurium, vecuronium, cisatracurium, rocuronium, or rapacuronium in guinea pigs. Mivacurium, at high doses, increased pulmonary inflation pressures, which were attenuated by pyrilamine. Reference: Anesthesiology. 2007 Apr;106(4):763-72. https://pubmed.ncbi.nlm.nih.gov/17413914/
Solvent mg/mL mM comments
Solubility
DMSO 175.0 159.07
Ethanol 100.0 90.89
Water 100.0 90.89
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 1,100.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Che D, Wang J, Ding Y, Liu R, Cao J, Zhang Y, Hou Y, An H, Gao Z, Zhang T. Mivacurium induce mast cell activation and pseudo-allergic reactions via MAS-related G protein coupled receptor-X2. Cell Immunol. 2018 Oct;332:121-128. doi: 10.1016/j.cellimm.2018.08.005. Epub 2018 Aug 10. PMID: 30121125. 2. Yang HS, Goudsouzian N, Martyn JA. Pseudocholinesterase-mediated hydrolysis is superior to neostigmine for reversal of mivacurium-induced paralysis in vitro. Anesthesiology. 1996 Apr;84(4):936-44. doi: 10.1097/00000542-199604000-00022. PMID: 8638849. 3. Jooste E, Zhang Y, Emala CW. Neuromuscular blocking agents' differential bronchoconstrictive potential in Guinea pig airways. Anesthesiology. 2007 Apr;106(4):763-72. doi: 10.1097/01.anes.0000264763.48920.c9. PMID: 17413914.
In vitro protocol:
1. Che D, Wang J, Ding Y, Liu R, Cao J, Zhang Y, Hou Y, An H, Gao Z, Zhang T. Mivacurium induce mast cell activation and pseudo-allergic reactions via MAS-related G protein coupled receptor-X2. Cell Immunol. 2018 Oct;332:121-128. doi: 10.1016/j.cellimm.2018.08.005. Epub 2018 Aug 10. PMID: 30121125. 2. Yang HS, Goudsouzian N, Martyn JA. Pseudocholinesterase-mediated hydrolysis is superior to neostigmine for reversal of mivacurium-induced paralysis in vitro. Anesthesiology. 1996 Apr;84(4):936-44. doi: 10.1097/00000542-199604000-00022. PMID: 8638849.
In vivo protocol:
1. Jooste E, Zhang Y, Emala CW. Neuromuscular blocking agents' differential bronchoconstrictive potential in Guinea pig airways. Anesthesiology. 2007 Apr;106(4):763-72. doi: 10.1097/01.anes.0000264763.48920.c9. PMID: 17413914.
1: Vanlinthout LE, Mesfin SH, Hens N, Vanacker BF, Robertson EN, Booij LH. A systematic review and meta-regression analysis of mivacurium for tracheal intubation. Anaesthesia. 2014 Dec;69(12):1377-87. doi: 10.1111/anae.12786. Epub 2014 Jul 10. Review. PubMed PMID: 25040541. 2: Sayson SC, Mongan PD. Onset of action of mivacurium chloride. A comparison of neuromuscular blockade monitoring at the adductor pollicis and the orbicularis oculi. Anesthesiology. 1994 Jul;81(1):35-42. PubMed PMID: 8042808. 3: Tercan M, Efe EM, Turker G, Kaya FN, Yavascaoglu B, Ozarda Y, Mogol EB. Do metoclopramide and ondansetrone alter mivacurium-induced neuromuscular blockade? - a randomised trial. Braz J Anesthesiol. 2014 Jan-Feb;64(1):35-9. doi: 10.1016/j.bjane.2013.04.008. Epub 2013 Dec 7. PubMed PMID: 24565386. 4: Xin Y, Guo Y, Jiang Y, Zhang H. [Effects of pri ming different low-dose rocurium on pharmacodynamics of mivacurium]. Zhonghua Yi Xue Za Zhi. 2014 Jun 3;94(21):1647-50. Chinese. PubMed PMID: 25152289. 5: Meretoja OA, Taivainen T. Mivacurium chloride in infants and children. Acta Anaesthesiol Scand Suppl. 1995;106:41-4. PubMed PMID: 8533544. 6: Ali HH, Savarese JJ, Embree PB, Basta SJ, Stout RG, Bottros LH, Weakly JN. Clinical pharmacology of mivacurium chloride (BW B1090U) infusion: comparison with vecuronium and atracurium. Br J Anaesth. 1988 Nov;61(5):541-6. PubMed PMID: 2905143. 7: Smith LJ, Schwark WS, Cook DR, Moon PF, Looney AL. Pharmacokinetic variables of mivacurium chloride after intravenous administration in dogs. Am J Vet Res. 1999 Sep;60(9):1051-4. PubMed PMID: 10490070. 8: Ortiz JR, Carrascosa F. [Mivacurium]. Rev Esp Anestesiol Reanim. 1997 Oct;44(8):315-20. Review. Spanish. PubMed PMID: 9424685. 9: Wicks TC. Mivacurium chloride. Nurse Anesth. 1992 Dec;3(4):173-82. Review. PubMed PMID: 1290779. 10: Basta SJ. Clinical pharmacology of mivacurium chloride: a review. J Clin Anesth. 1992 Mar-Apr;4(2):153-63. Review. PubMed PMID: 1373287. 11: From RP, Pearson KS, Choi WW, Abou-Donia M, Sokoll MD. Neuromuscular and cardiovascular effects of mivacurium chloride (BW B1090U) during nitrous oxide-fentanyl-thiopentone and nitrous oxide-halothane anaesthesia. Br J Anaesth. 1990 Feb;64(2):193-8. PubMed PMID: 2138490. 12: Xiang Z, Yan-Liang Q, Xiao-Yang S, Yan-Hui Z, Min C, Guo-Shen G, Ming-Chun W, Zhong-Bing L, Qing-Li W, Guang-Jun H, Ming-Zhe Q, Jun T. Effects of promethazine or dexamethasone pretreatment on mivacurium-induced histamine release in children. Paediatr Anaesth. 2014 Mar;24(3):322-6. doi: 10.1111/pan.12305. Epub 2013 Nov 15. PubMed PMID: 24238032. 13: Pendeville PE, Laloyaux P, Fraselle B, Van Boven MJ. Mivacurium chloride for short laparoscopic procedures. Acta Anaesthesiol Belg. 1995;46(3-4):161-8. PubMed PMID: 8669222. 14: Poler SM, Watcha MF, White PF. Mivacurium as an alternative to succinylcholine during outpatient laparoscopy. J Clin Anesth. 1992 Mar-Apr;4(2):127-33. PubMed PMID: 1532896. 15: Wichmann S, Færk G, Bundgaard JR, Gätke MR. Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene. Pharmacogenet Genomics. 2016 Jul;26(7):351-6. doi: 10.1097/FPC.0000000000000221. PubMed PMID: 27031121. 16: Smith LJ, Moon PF, Lukasik VM, Erb HN. Duration of action and hemodynamic properties of mivacurium chloride in dogs anesthetized with halothane. Am J Vet Res. 1999 Sep;60(9):1047-50. PubMed PMID: 10490069. 17: Jahr JS, Keller T, Williams MD, Liukkonen JR, Anwar M, Paxtor CG, Greene M, Gitlin MC. To reverse or not to reverse: an evaluation of reversal of mivacurium chloride in women undergoing outpatient gynecological procedures. Am J Ther. 1997 Sep-Oct;4(9-10):315-22. PubMed PMID: 10423625. 18: Jalkanen L, Meretoja OA, Taivainen T, Brandom BW, Dayal B. Synergism between atracurium and mivacurium compared with that between vecuronium and mivacurium. Anesth Analg. 1994 Nov;79(5):998-1002. PubMed PMID: 7978423. 19: Phillips BJ, Hunter JM. Use of mivacurium chloride by constant infusion in the anephric patient. Br J Anaesth. 1992 May;68(5):492-8. PubMed PMID: 1642938. 20: Ting CK, Lin SM, Yang YW, Tsai HJ, Lao HC, Chu YC, Tsai SK. Reversal of mivacurium chloride: edrophonium of spontaneous recovery in microscopic laryngeal surgery. Acta Anaesthesiol Sin. 2001 Dec;39(4):157-62. PubMed PMID: 11840581.