VU 6010572 | CAS#2126784-39-0 | Antidepressant

MedKoo Cat#: 571266 | Name: VU 6010572

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU 6010572 is a negative allosteric modulator (NAM) for mGlu. VU 6010572 has an IC50 of 245 nM for mGlu3 with high selectivity among all mGlu receptors. VU 6010572 is highly CNS penetrant.

Chemical Structure

VU 6010572

CAS#2126784-39-0

Theoretical Analysis

MedKoo Cat#: 571266

Name: VU 6010572

CAS#: 2126784-39-0

Chemical Formula: C20H18FNO3

Exact Mass: 339.1271

Molecular Weight: 339.37

Elemental Analysis: C, 70.78; H, 5.35; F, 5.60; N, 4.13; O, 14.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

2126784-38-9 (R-isomer) 2126784-39-0 1982308-95-1 (racemic)

Synonym

VU 6010572; VU-6010572; VU6010572

IUPAC/Chemical Name

(S)-1-(4-fluorophenyl)-4-(2-phenoxypropoxy)pyridin-2(1H)-one

InChi Key

AUMJXOXUSGIUCB-HNNXBMFYSA-N

InChi Code

InChI=1S/C20H18FNO3/c1-15(25-18-5-3-2-4-6-18)14-24-19-11-12-22(20(23)13-19)17-9-7-16(21)8-10-17/h2-13,15H,14H2,1H3/t15-/m0/s1

SMILES Code

FC(C=C1)=CC=C1N2C=CC(OC[C@H](C)OC3=CC=CC=C3)=CC2=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Negative allosteric modulators (NAM) are molecules of interest in treating depression-related behaviors, as potentially novel antidepressants.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 339.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Engers JL, Bollinger KA; Weiner RL, Rodriguez AL, Long MF, Breiner MM, Chang S, Bollinger SR, Bubser M, Jones CK, Morrison RD, Bridges TM, Blobaum AL, Niswender CM, Conn JP, Emmitte KA, Lindsley CW. Design and Synthesis of N‑Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs. ACS Med Chem. 2017 Aug 15. doi: 10.1021/acsmedchemlett.7b00249. [Epub ahead of print].