A 69992 | CAS# 138921-14-9 | HIV Antiviral

MedKoo Cat#: 571170 | Name: A 69992

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A 69992 is an HIV anti-infective nucleoside. Its enantiomers (see Synonyms) also show anti-HIV activity.

Chemical Structure

A 69992

CAS#138921-14-9

Theoretical Analysis

MedKoo Cat#: 571170

Name: A 69992

CAS#: 138921-14-9

Chemical Formula: C11H14TN5O3

Exact Mass: 267.1257

Molecular Weight: 267.28

Elemental Analysis: C, 49.43; H, 6.41; N, 26.20; O, 17.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

A 69992; A-69992; A69992; Abbott 69992; A 75962; A-75962; A75962; A 75179; A75179; A-75179;

IUPAC/Chemical Name

6H-Purin-6-one-8-t,2-amino-9-(2,3-bis(hydroxymethyl)cyclobutyl)-1,9-dihydro-, (1alpha,2beta,3alpha)-(+-)-

InChi Key

GWFOVSGRNGAGDL-WMTWEQRYSA-N

InChi Code

InChI=1S/C11H15N5O3/c12-11-14-9-8(10(19)15-11)13-4-16(9)7-1-5(2-17)6(7)3-18/h4-7,17-18H,1-3H2,(H3,12,14,15,19)/t5-,6-,7-/m0/s1/i4T

SMILES Code

O=C1NC(N)=NC2=C1N=C([3H])N2[C@@H]3[C@@H](CO)[C@H](CO)C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 267.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Thomas SB, Surber BW. Preparative separation and analysis of the enantiomers of [3H]Abbott-69992, an HIV anti-infective nucleoside, by ligand exchange high-performance liquid chromatography. J Chromatogr. 1991 Nov 22;586(2):265-70. PubMed PMID: 1810972. 2: Kohlbrenner WE, Carter CD, Fesik SW, Norbeck DW, Erickson J. Efficiency of phosphorylation of the cyclobut-G (A-69992) enantiomers by HSV-1 thymidine kinase does not correlate with their anti-herpesvirus activity. Biochem Pharmacol. 1990 Dec 1;40(11):R5-10. PubMed PMID: 2176497.