MedKoo Cat#: 530683 | Name: MDK3465
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDK3465, also known as PTP1B-IN-2, is a potent and selective protein tyrosine phosphatase-1B (PTP1B) inhibitor. MDK3465 has CAS#1919853-46-5. The last 4 digit of its CAS# is used for name.

Chemical Structure

MDK3465
MDK3465
CAS#1919853-46-5

Theoretical Analysis

MedKoo Cat#: 530683

Name: MDK3465

CAS#: 1919853-46-5

Chemical Formula: C34H36N2O9S2

Exact Mass: 680.1862

Molecular Weight: 680.79

Elemental Analysis: C, 59.99; H, 5.33; N, 4.11; O, 21.15; S, 9.42

Price and Availability

Size Price Availability Quantity
25mg USD 285.00 2 Weeks
50mg USD 500.00 2 Weeks
100mg USD 850.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
PTP1B-IN-2; PTP1B-IN-2; PTP1B-IN-2; MDK3465; MDK-3465; MDK 3465.
IUPAC/Chemical Name
5-[[[4-[(2-methoxy-2-oxoethyl)(methylsulfonyl)amino]phenyl]methyl][(phenylmethyl)sulfonyl]amino]-2-[(4-methylphenyl)methoxy]-benzoic acid, methyl ester
InChi Key
IPNJQCVHNPGYOX-UHFFFAOYSA-N
InChi Code
InChI=1S/C34H36N2O9S2/c1-25-10-12-27(13-11-25)23-45-32-19-18-30(20-31(32)34(38)44-3)36(47(41,42)24-28-8-6-5-7-9-28)21-26-14-16-29(17-15-26)35(46(4,39)40)22-33(37)43-2/h5-20H,21-24H2,1-4H3
SMILES Code
O=C(OC)C1=CC(N(CC2=CC=C(N(CC(OC)=O)S(=O)(C)=O)C=C2)S(=O)(CC3=CC=CC=C3)=O)=CC=C1OCC4=CC=C(C)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 680.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Liu P, Du Y, Song L, Shen J, Li Q. Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity. Eur J Med Chem. 2016 Aug 8;118:27-33. doi: 10.1016/j.ejmech.2016.04.014. Epub 2016 Apr 9. PMID: 27123900.