TLK19781 | CAS#309932-60-3 | insulin receptor modulator

MedKoo Cat#: 561317 | Name: TLK19781

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TLK19781 is an insulin receptor modulator. In cultured cells made insulin resistant HIV by PI treatment, TLK19781 both increased the content of insulin-stimulated GLUT4 at the plasma membrane and enhanced insulin-stimulated glucose transport.

Chemical Structure

TLK19781

CAS#309932-60-3

Theoretical Analysis

MedKoo Cat#: 561317

Name: TLK19781

CAS#: 309932-60-3

Chemical Formula: C33H24Cl2N4O13S4

Exact Mass: 881.9600

Molecular Weight: 883.71

Elemental Analysis: C, 44.85; H, 2.74; Cl, 8.02; N, 6.34; O, 23.54; S, 14.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

TLK19781; TLK 19781; TLK-19781;

IUPAC/Chemical Name

5,5'-[Carbonylbis[imino(1-hydroxynaphthalene-6,3-diyl)sulfonylimino]]bis(2-chlorobenzenesulfonic acid)

InChi Key

SJIOPXRFHRQRRS-UHFFFAOYSA-N

InChi Code

InChI=1S/C33H24Cl2N4O13S4/c34-27-7-3-21(13-31(27)55(47,48)49)38-53(43,44)23-11-17-9-19(1-5-25(17)29(40)15-23)36-33(42)37-20-2-6-26-18(10-20)12-24(16-30(26)41)54(45,46)39-22-4-8-28(35)32(14-22)56(50,51)52/h1-16,38-41H,(H2,36,37,42)(H,47,48,49)(H,50,51,52)

SMILES Code

O=C(NC1=CC2=CC(S(NC3=CC=C(Cl)C(S(=O)(O)=O)=C3)(=O)=O)=CC(O)=C2C=C1)NC4=CC5=CC(S(NC6=CC=C(Cl)C(S(=O)(O)=O)=C6)(=O)=O)=CC(O)=C5C=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 883.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wu M, Dai G, Yao J, Hoyt S, Wang L, Mu J. Potentiation of insulin-mediated glucose lowering without elevated hypoglycemia risk by a small molecule insulin receptor modulator. PLoS One. 2015 Mar 23;10(3):e0122012. doi: 10.1371/journal.pone.0122012. eCollection 2015. PubMed PMID: 25799496; PubMed Central PMCID: PMC4370409. 2: Cheng M, Chen S, Schow SR, Manchem VP, Spevak WR, Cristobal CP, Shi S, Macsata RW, Lum RT, Goldfine ID, Keck JG. In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator. J Cell Biochem. 2004 Aug 15;92(6):1234-45. PubMed PMID: 15258906.