A 33853 | CAS# 80148-45-4 | Antibiotic

MedKoo Cat#: 571108 | Name: A 33853

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A 33853 is an antibiotic isolated from culture broth of Streptomyces sp. It is a tetraacetyl with an anhydride moeity.

Chemical Structure

A 33853

CAS#80148-45-4

Theoretical Analysis

MedKoo Cat#: 571108

Name: A 33853

CAS#: 80148-45-4

Chemical Formula: C20H13N3O6

Exact Mass: 391.0804

Molecular Weight: 391.34

Elemental Analysis: C, 61.38; H, 3.35; N, 10.74; O, 24.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

A 33853; A33853; A-33853

IUPAC/Chemical Name

4-Benzoxazolecarboxylic acid, 2-(3-hydroxy-2-(((3-hydroxy-2-pyridinyl)carbonyl)amino)phenyl)-

InChi Key

LJVDLJDWXVPUAB-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H13N3O6/c24-12-6-1-4-10(15(12)22-18(26)17-13(25)7-3-9-21-17)19-23-16-11(20(27)28)5-2-8-14(16)29-19/h1-9,24-25H,(H,22,26)(H,27,28)

SMILES Code

O=C(C1=C2N=C(C3=CC=CC(O)=C3NC(C4=NC=CC=C4O)=O)OC2=CC=C1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 391.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Michel KH, Boeck LD, Hoehn MM, Jones ND, Chaney MO. The discovery, fermentation, isolation, and structure of antibiotic A33853 and its tetraacetyl derivative. J Antibiot (Tokyo). 1984 May;37(5):441-5. PubMed PMID: 6547431. 2: Tipparaju SK, Joyasawal S, Pieroni M, Kaiser M, Brun R, Kozikowski AP. In pursuit of natural product leads: synthesis and biological evaluation of 2-[3 hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4-carboxylic acid (A-33853) and its analogues: discovery of N-(2-benzoxazol2-ylphenyl)benzamides as novel antileishmanial chemotypes. J Med Chem. 2008 Dec 11;51(23):7344-7. doi: 10.1021/jm801241n. PubMed PMID: 18989953. 3: Lv M, Zhao J, Deng Z, Yu Y. Characterization of the Biosynthetic Gene Cluster for Benzoxazole Antibiotics A33853 Reveals Unusual Assembly Logic. Chem Biol. 2015 Oct 22;22(10):1313-24. doi: 10.1016/j.chembiol.2015.09.005. PubMed PMID: 26496684.