Dihydrocelastrol, also known as DHCE and Triptohypol C, is synthesized by hydrogenation of celastrol, which is a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE could inhibit cellular proliferation and induce cell apoptosis in myeloma cells mediated through different mechanisms, possibly through inhibiting the IL-6/STAT3 and ERK1/2 pathways. And it may provide a new therapeutic option for MM patients.
MedKoo Cat#: 406701
Name: Dihydrocelastrol
CAS#: 193957-88-9 (dihydrocelastrol)
Chemical Formula: C29H40O4
Exact Mass: 452.2927
Molecular Weight: 452.64
Elemental Analysis: C, 76.95; H, 8.91; O, 14.14
The following data is based on the product molecular weight 452.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
