Synonym
QC6352; QC-6352; QC 6352.
IUPAC/Chemical Name
(R)-3-(((6-(methyl(phenyl)amino)-1,2,3,4-tetrahydronaphthalen-1-yl)methyl)amino)isonicotinic acid
InChi Key
XSMABFRQESMONQ-SFHVURJKSA-N
InChi Code
InChI=1S/C24H25N3O2/c1-27(19-8-3-2-4-9-19)20-10-11-21-17(14-20)6-5-7-18(21)15-26-23-16-25-13-12-22(23)24(28)29/h2-4,8-14,16,18,26H,5-7,15H2,1H3,(H,28,29)/t18-/m0/s1
SMILES Code
O=C(O)C1=CC=NC=C1NC[C@@H]2CCCC3=C2C=CC(N(C)C4=CC=CC=C4)=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
KDM4 genes and proteins are overexpressed in numerous tumor types including breast, colorectal, pancreatic, lymphoma, and gastric cancers. KDM4 family members also play an important role in the epigenetic regulation of embryonic stem cell identity.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
387.48
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models
ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00220
Young K. Chen,† Tiziana Bonaldi,# Alessandro Cuomo,# Joselyn R. Del Rosario,† David J. Hosfield,§
Toufike Kanouni,† Shih-chu Kao,‡,● Chon Lai,† Neethan A. Lobo,‡ Jennifer Matuszkiewicz,†
Andrew McGeehan,‡ Shawn M. O’Connell,†,▲ Lihong Shi,† Jeffrey A. Stafford,†,■ Ryan K. Stansfield,†,■
James M. Veal,†,■ Michael S. Weiss,‡,□ Natalie Y. Yuen,‡ and Michael B. Wallace*,†
†Celgene Quanticel Research, 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States
‡Celgene Quanticel Research, 1500 Owens Street, Suite 500, San Francisco, California 94158, United States
#Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milano, Italy
§Ben May Department for Cancer Research, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, United States
