Quindonium bromide | CAS# 130-81-4 | Cardiac Depressant (Anti-Arrhythmic)

MedKoo Cat#: 412823 | Name: Quindonium bromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Quindonium bromide is a Cardiac Depressant (Anti-Arrhythmic)

Chemical Structure

Quindonium bromide

CAS#130-81-4

Theoretical Analysis

MedKoo Cat#: 412823

Name: Quindonium bromide

CAS#: 130-81-4

Chemical Formula: C16H20BrNO

Exact Mass: 321.0728

Molecular Weight: 322.25

Elemental Analysis: C, 59.64; H, 6.26; Br, 24.80; N, 4.35; O, 4.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Quindonium bromide; W3366A; W-3366A; W 3366A

IUPAC/Chemical Name

1H-Benzo(a)cyclopenta(f)quinolizinium, 2,3,3a,5,6,11,12,12a-octahydro-8-hydroxy-, bromide

InChi Key

OUILVKYDBNPYBM-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H19NO.BrH/c18-13-5-6-14-12(10-13)8-9-17-15-3-1-2-11(15)4-7-16(14)17;/h5-6,10-11,15H,1-4,7-9H2;1H

SMILES Code

OC1=CC=C2C(CC[N+]3=C2CCC4C3CCC4)=C1.[Br-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 322.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: OSBORNE MW, WINBURY MM. QUINDONIUM BROMIDE--SOME ASPECTS OF THE CARDIOVASCULAR PHARMACOLOGY. J Pharmacol Exp Ther. 1965 Feb;147:212-24. PMID: 14259499. 2: Kaplan HR, La Sala SA. Quindonium bromide: cardiac rate and rhythm disturbances in barbiturate. Anesthetized dogs. J Pharmacol Exp Ther. 1972 Apr;181(1):98-107. PMID: 5013159. 3: Gupta RS, Chopra A, Stetsko DK. Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis). J Cell Physiol. 1986 May;127(2):197-206. doi: 10.1002/jcp.1041270202. PMID: 3009493. 4: Lum BK, Allen DO. Protection against traumatic shock by pretreatment with quindonium bromide. Arch Int Pharmacodyn Ther. 1967 Sep;169(1):185-8. PMID: 6055127. 5: Gupta RS, Chopra A. Cross-resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides. The unusual behavior of cardenolide SC4453. J Biol Chem. 1985 Jun 10;260(11):6843-50. PMID: 2987235. 6: OSBORNE MW, ROWE HM, KAUFMAN RN, JOHNSON MC, WILLEMS W, WINBURY MM. PROTECTIVE ACTION OF QUINDONIUM BROMIDE (W3366A) AGAINST HEMORRHAGE SHOCK IN DOGS. J Pharmacol Exp Ther. 1965 Feb;147:225-31. PMID: 14259500.