Sepin-1 is a noncompetitive inhibitor of separase. Sepin-1 inhibits separase enzymatic activity with a half maximal inhibitory concentration (IC50) of 14.8 µM. Sepin-1 can inhibit the growth of human cancer cell lines and breast cancer xenograft tumors in mice by inhibiting cell proliferation and inducing apoptosis.
MedKoo Cat#: 561256
Name: Sepin-1
CAS#: 163126-81-6
Chemical Formula: C9H9N3O4
Exact Mass: 223.0593
Molecular Weight: 223.19
Elemental Analysis: C, 48.43; H, 4.06; N, 18.83; O, 28.67
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMSO | 100.0 | 448.05 |
The following data is based on the product molecular weight 223.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
