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MedKoo Cat#: 561242 | Name: Alrestatin Sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Alrestatin is a specific inhibitor of the aldose reductase enzyme. Alrestatin also inhibited gastric acid secretion and decreased the volume of gastric juice produced in pylorus-ligated rats. It is structurally related to tolrestat, another ARI that was briefly marketed before being withdrawn in 1997.

Chemical Structure

Alrestatin Sodium
Alrestatin Sodium
CAS#51876-97-2 (sodium)

Theoretical Analysis

MedKoo Cat#: 561242

Name: Alrestatin Sodium

CAS#: 51876-97-2 (sodium)

Chemical Formula: C14H8NNaO4

Exact Mass: 0.0000

Molecular Weight: 277.21

Elemental Analysis: C, 60.66; H, 2.91; N, 5.05; Na, 8.29; O, 23.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
51876-97-2 (sodium) 51411-04-2 (free acid)
Synonym
Alrestatin Sodium; Alrestatine sodium; AY-22284A; AY 22284A; AY22284A
IUPAC/Chemical Name
Sodium 2-(1,3-Dioxobenzo[de]isoquinolin-2-yl)acetate
InChi Key
FKZUETPACPDEAD-UHFFFAOYSA-M
InChi Code
InChI=1S/C14H9NO4.Na/c16-11(17)7-15-13(18)9-5-1-3-8-4-2-6-10(12(8)9)14(15)19;/h1-6H,7H2,(H,16,17);/q;+1/p-1
SMILES Code
O=C([O-])CN(C(C1=CC=CC2=CC=CC3=C12)=O)C3=O.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 277.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lippmann W, Seethaler K, Borella LE, Pugsley TA. Alrestatin: gastric acid antisecretory-antiulcer activity in the rat. Digestion. 1978;18(1-2):35-44. PubMed PMID: 103765. 2: Kobric M, Lippmann W. Effect of alrestatin sodium on glucose-stimulated insulin secretion in the fasted anaesthetized rat. Horm Metab Res. 1978 Nov;10(6):495-500. PubMed PMID: 744568. 3: Srivastava SK, Ansari NH, Bhatnagar A, Hair G, Liu S, Das B. Activation of aldose reductase by nonenzymatic glycosylation. Prog Clin Biol Res. 1989;304:171-84. PubMed PMID: 2506561. 4: Brogard JM, Caro-Sampara F, Blicklé JF. [Role of polyols in the development of diabetic complications. Value of aldose-reductase inhibitors]. Rev Med Interne. 1992 Jan-Feb;13(1):69-79. Review. French. PubMed PMID: 1410879. 5: Morjana NA, Flynn TG. Aldose reductase from human psoas muscle. Purification, substrate specificity, immunological characterization, and effect of drugs and inhibitors. J Biol Chem. 1989 Feb 15;264(5):2906-11. PubMed PMID: 2492526. 6: Das B, Srivastava SK. Purification and properties of aldose reductase and aldehyde reductase II from human erythrocyte. Arch Biochem Biophys. 1985 May 1;238(2):670-9. PubMed PMID: 3922304. 7: Cromlish JA, Flynn TG. Purification and characterization of two aldose reductase isoenzymes from rabbit muscle. J Biol Chem. 1983 Mar 10;258(5):3416-24. PubMed PMID: 6402510.