MedKoo Cat#: 561214 | Name: UCL2077
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

UCL2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker. UCL2077 suppresses the sAHP present in hippocampal neurons in culture and in the slice preparation. UCL2077 is selective and has minimal effects on Ca(2+) channels, action potentials, input resistance and the medium afterhyperpolarization.

Chemical Structure

UCL2077
UCL2077
CAS#918311-87-2

Theoretical Analysis

MedKoo Cat#: 561214

Name: UCL2077

CAS#: 918311-87-2

Chemical Formula: C25H22N2

Exact Mass: 350.1783

Molecular Weight: 350.47

Elemental Analysis: C, 85.68; H, 6.33; N, 7.99

Price and Availability

Size Price Availability Quantity
10mg USD 350.00
20mg USD 600.00
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Related CAS #
No Data
Synonym
UCL2077, UCL 2077, UCL-2077
IUPAC/Chemical Name
1,1,1-triphenyl-N-(pyridin-3-ylmethyl)methanamine
InChi Key
PQFNWDHABGBCHB-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H22N2/c1-4-12-22(13-5-1)25(23-14-6-2-7-15-23,24-16-8-3-9-17-24)27-20-21-11-10-18-26-19-21/h1-19,27H,20H2
SMILES Code
C1(C(NCC2=CN=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=CC=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 350.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Constantin S, Quignon C, Pizano K, Shostak DM, Wray S. Vasoactive intestinal peptide excites GnRH neurons via KCa3.1, a potential player in the slow afterhyperpolarization current. Front Cell Neurosci. 2024 Apr 3;18:1354095. doi: 10.3389/fncel.2024.1354095. PMID: 38633445; PMCID: PMC11021707. 2: Wu SN, Wu CL, Cho HY, Chiang CW. Effective Perturbations by Small-Molecule Modulators on Voltage-Dependent Hysteresis of Transmembrane Ionic Currents. Int J Mol Sci. 2022 Aug 21;23(16):9453. doi: 10.3390/ijms23169453. PMID: 36012718; PMCID: PMC9408818. 3: Hsu HT, Lo YC, Wu SN. Characterization of Convergent Suppression by UCL-2077 (3-(Triphenylmethylaminomethyl)pyridine), Known to Inhibit Slow Afterhyperpolarization, of erg-Mediated Potassium Currents and Intermediate-Conductance Calcium-Activated Potassium Channels. Int J Mol Sci. 2020 Feb 20;21(4):1441. doi: 10.3390/ijms21041441. PMID: 32093314; PMCID: PMC7073080. 4: Ishibashi M, Gumenchuk I, Miyazaki K, Inoue T, Ross WN, Leonard CS. Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization. J Neurosci. 2016 Sep 28;36(39):10097-115. doi: 10.1523/JNEUROSCI.0635-16.2016. Epub 2016 Sep 28. PMID: 27683906; PMCID: PMC5039256. 5: Zhang L, Ouyang M, Ganellin CR, Thomas SA. The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval. J Neurosci. 2013 Mar 13;33(11):5006-16. doi: 10.1523/JNEUROSCI.3834-12.2013. PMID: 23486971; PMCID: PMC3632069. 6: Zaitsev AV, Anwyl R. Inhibition of the slow afterhyperpolarization restores the classical spike timing-dependent plasticity rule obeyed in layer 2/3 pyramidal cells of the prefrontal cortex. J Neurophysiol. 2012 Jan;107(1):205-15. doi: 10.1152/jn.00452.2011. Epub 2011 Oct 5. PMID: 21975445. 7: Duan W, Lee K, Herbison AE, Sneyd J. A mathematical model of adult GnRH neurons in mouse brain and its bifurcation analysis. J Theor Biol. 2011 May 7;276(1):22-34. doi: 10.1016/j.jtbi.2011.01.035. Epub 2011 Feb 25. PMID: 21300070. 8: Soh H, Tzingounis AV. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol Pharmacol. 2010 Dec;78(6):1088-95. doi: 10.1124/mol.110.066100. Epub 2010 Sep 15. PMID: 20843955; PMCID: PMC2993466. 9: Zhang L, Kolaj M, Renaud LP. Ca2+-dependent and Na+-dependent K+ conductances contribute to a slow AHP in thalamic paraventricular nucleus neurons: a novel target for orexin receptors. J Neurophysiol. 2010 Oct;104(4):2052-62. doi: 10.1152/jn.00320.2010. Epub 2010 Aug 18. PMID: 20719929. 10: Lee K, Duan W, Sneyd J, Herbison AE. Two slow calcium-activated afterhyperpolarization currents control burst firing dynamics in gonadotropin- releasing hormone neurons. J Neurosci. 2010 May 5;30(18):6214-24. doi: 10.1523/JNEUROSCI.6156-09.2010. PMID: 20445047; PMCID: PMC6632712. 11: Zhang L, Renaud LP, Kolaj M. Properties of a T-type Ca2+channel-activated slow afterhyperpolarization in thalamic paraventricular nucleus and other thalamic midline neurons. J Neurophysiol. 2009 Jun;101(6):2741-50. doi: 10.1152/jn.91183.2008. Epub 2009 Mar 25. PMID: 19321637. 12: Shah MM, Javadzadeh-Tabatabaie M, Benton DC, Ganellin CR, Haylett DG. Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol Pharmacol. 2006 Nov;70(5):1494-502. doi: 10.1124/mol.106.026625. Epub 2006 Jul 28. PMID: 16877678; PMCID: PMC2346772.