Synonym
UCL2077, UCL 2077, UCL-2077
IUPAC/Chemical Name
1,1,1-triphenyl-N-(pyridin-3-ylmethyl)methanamine
InChi Key
PQFNWDHABGBCHB-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H22N2/c1-4-12-22(13-5-1)25(23-14-6-2-7-15-23,24-16-8-3-9-17-24)27-20-21-11-10-18-26-19-21/h1-19,27H,20H2
SMILES Code
C1(C(NCC2=CN=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=CC=CC=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
350.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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3: Hsu HT, Lo YC, Wu SN. Characterization of Convergent Suppression by UCL-2077 (3-(Triphenylmethylaminomethyl)pyridine), Known to Inhibit Slow Afterhyperpolarization, of erg-Mediated Potassium Currents and Intermediate-Conductance Calcium-Activated Potassium Channels. Int J Mol Sci. 2020 Feb 20;21(4):1441. doi: 10.3390/ijms21041441. PMID: 32093314; PMCID: PMC7073080.
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6: Zaitsev AV, Anwyl R. Inhibition of the slow afterhyperpolarization restores the classical spike timing-dependent plasticity rule obeyed in layer 2/3 pyramidal cells of the prefrontal cortex. J Neurophysiol. 2012 Jan;107(1):205-15. doi: 10.1152/jn.00452.2011. Epub 2011 Oct 5. PMID: 21975445.
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8: Soh H, Tzingounis AV. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol Pharmacol. 2010 Dec;78(6):1088-95. doi: 10.1124/mol.110.066100. Epub 2010 Sep 15. PMID: 20843955; PMCID: PMC2993466.
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10: Lee K, Duan W, Sneyd J, Herbison AE. Two slow calcium-activated afterhyperpolarization currents control burst firing dynamics in gonadotropin- releasing hormone neurons. J Neurosci. 2010 May 5;30(18):6214-24. doi: 10.1523/JNEUROSCI.6156-09.2010. PMID: 20445047; PMCID: PMC6632712.
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12: Shah MM, Javadzadeh-Tabatabaie M, Benton DC, Ganellin CR, Haylett DG. Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol Pharmacol. 2006 Nov;70(5):1494-502. doi: 10.1124/mol.106.026625. Epub 2006 Jul 28. PMID: 16877678; PMCID: PMC2346772.
