K118 HCl CAS#54156-23-9 | SHIP1 inhibitor

MedKoo Cat#: 561207 | Name: K118 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

K118 is a water soluble inhibitor of SH2-containing inositol 5' phosphatase 1 (SHIP1). K118 reverses age- and diet-associated obesity and metabolic syndrome.

Chemical Structure

K118 HCl

CAS#54156-23-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 561207

Name: K118 HCl

CAS#: 54156-23-9 (HCl)

Chemical Formula: C19H34ClN

Exact Mass: 311.2380

Molecular Weight: 311.94

Elemental Analysis: C, 73.16; H, 10.99; Cl, 11.36; N, 4.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

54156-22-8 (free base) 54156-23-9 (HCl)

Synonym

K118; K 118; K-118; K118 HCl; K118 hydrochloride

IUPAC/Chemical Name

(3S,5S,8S,9S,10S,13S,14S)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-amine hydrochloride

InChi Key

YRFZFBDCFRITSB-NKPAQCGESA-N

InChi Code

InChI=1S/C19H33N.ClH/c1-18-9-3-4-16(18)15-6-5-13-12-14(20)7-11-19(13,2)17(15)8-10-18;/h13-17H,3-12,20H2,1-2H3;1H/t13-,14-,15-,16-,17-,18-,19-;/m0./s1

SMILES Code

N[C@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@@]4(C)[C@H]3CCC4)C1.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 311.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Brooks R, Iyer S, Akada H, Neelam S, Russo CM, Chisholm JD, Kerr WG. Coordinate expansion of murine hematopoietic and mesenchymal stem cell compartments by SHIPi. Stem Cells. 2015 Mar;33(3):848-58. doi: 10.1002/stem.1902. PubMed PMID: 25402778. 2: Srivastava N, Iyer S, Sudan R, Youngs C, Engelman RW, Howard KT, Russo CM, Chisholm JD, Kerr WG. A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome. JCI Insight. 2016 Jul 21;1(11). pii: e88544. PubMed PMID: 27536730; PubMed Central PMCID: PMC4985248.