Related CAS #
1204737-52-9 (HCl)
1204737-09-6 (free base)
Synonym
LY2607540; LY-2607540; LY 2607540; THIIC
IUPAC/Chemical Name
N-({4-[3-hydroxy-4-(2-methylpropanoyl)-2-(trifluoromethyl)phenoxymethyl]phenyl}methyl)-1-methyl-1H-imidazole-4-carboxamide
InChi Key
RYINQFMHVVYWNS-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H24F3N3O4/c1-14(2)21(31)17-8-9-19(20(22(17)32)24(25,26)27)34-12-16-6-4-15(5-7-16)10-28-23(33)18-11-30(3)13-29-18/h4-9,11,13-14,32H,10,12H2,1-3H3,(H,28,33)
SMILES Code
O=C(C1=CN(C)C=N1)NCC2=CC=C(COC3=CC=C(C(C(C)C)=O)C(O)=C3C(F)(F)F)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
475.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Fell MJ, Witkin JM, Falcone JF, Katner JS, Perry KW, Hart J, Rorick-Kehn L,
Overshiner CD, Rasmussen K, Chaney SF, Benvenga MJ, Li X, Marlow DL, Thompson LK,
Luecke SK, Wafford KA, Seidel WF, Edgar DM, Quets AT, Felder CC, Wang X, Heinz
BA, Nikolayev A, Kuo MS, Mayhugh D, Khilevich A, Zhang D, Ebert PJ, Eckstein JA,
Ackermann BL, Swanson SP, Catlow JT, Dean RA, Jackson K, Tauscher-Wisniewski S,
Marek GJ, Schkeryantz JM, Svensson KA.
N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methy
l-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2
potentiator with potential anxiolytic/antidepressant properties: in vivo
profiling suggests a link between behavioral and central nervous system
neurochemical changes. J Pharmacol Exp Ther. 2011 Jan;336(1):165-77. doi:
10.1124/jpet.110.172957. Epub 2010 Oct 14. PubMed PMID: 20947638.
2: Johnson PL, Fitz SD, Engleman EA, Svensson KA, Schkeryantz JM, Shekhar A.
Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent
sodium lactate-induced panic-like response in panic-vulnerable rats. J
Psychopharmacol. 2013 Feb;27(2):152-61. doi: 10.1177/0269881112454230. Epub 2012
Aug 21. PubMed PMID: 22914798; PubMed Central PMCID: PMC4300988.
