U-101958 Maleate | CAS#224170-09-6 | Dopamine D4 Receptor Ligand

MedKoo Cat#: 561155 | Name: U-101958 Maleate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

U-101958 Maleate is a dopamine D4 receptor ligand. U-101958 Maleate also binds to a large sigma1 receptor-like component in human cerebellum and SK-N-MC neuroblastoma cells with high affinity.

Chemical Structure

U-101958 Maleate

CAS#224170-09-6

Theoretical Analysis

MedKoo Cat#: 561155

Name: U-101958 Maleate

CAS#: 224170-09-6

Chemical Formula: C25H33N3O5

Exact Mass:

Molecular Weight: 455.56

Elemental Analysis: C, 65.91; H, 7.30; N, 9.22; O, 17.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

U-101958 Maleate, U 101958 Maleate, U101958 Maleate, U101958, U 101958, U-101958

IUPAC/Chemical Name

N-[1-Benzylpiperidin-4-yl]-N-methyl-3-propan-2-yloxypyridin-2-amine Maleate

InChi Key

KPYPLDPMBWPEBO-BTJKTKAUSA-N

InChi Code

InChI=1S/C21H29N3O.C4H4O4/c1-17(2)25-20-10-7-13-22-21(20)23(3)19-11-14-24(15-12-19)16-18-8-5-4-6-9-18;5-3(6)1-2-4(7)8/h4-10,13,17,19H,11-12,14-16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code

CC(OC1=CC=CN=C1N(C2CCN(CC3=CC=CC=C3)CC2)C)C.O=C(O)/C=C\C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 455.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gazi L, Bobirnac I, Danzeisen M, Schüpbach E, Langenegger D, Sommer B, Hoyer D, Tricklebank M, Schoeffter P. Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L-745,870 and U-101958 at human recombinant D4.4 receptors expressed in CHO cells. Br J Pharmacol. 1999 Oct;128(3):613-20. PubMed PMID: 10516640; PubMed Central PMCID: PMC1571689. 2: Helmeste DM, Shioiri T, Mitsuhashi M, Tang SW. Binding of [3H]U-101958 to sigma1 receptor-like sites in human cerebellum and neuroblastoma cells. Eur J Pharmacol. 1999 Apr 9;370(2):205-9. PubMed PMID: 10323271. 3: Gazi L, Bobirnac I, Danzeisen M, Schüpbach E, Bruinvels AT, Geisse S, Sommer B, Hoyer D, Tricklebank M, Schoeffter P. The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor. Br J Pharmacol. 1998 Jul;124(5):889-96. PubMed PMID: 9692773; PubMed Central PMCID: PMC1565470.