MedKoo Cat#: 561070 | Name: 4-Fluorophenylalanine HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

4-Fluorophenylalanine, also known as (S)-4-Fluorophenylalanine, L-4-Fluorophenylalanine and p-fluorophenylalanine, inhibits mitosis and reversible arrests HeLa cells in G2 phase.

Chemical Structure

4-Fluorophenylalanine HCl
4-Fluorophenylalanine HCl
CAS#122839-52-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 561070

Name: 4-Fluorophenylalanine HCl

CAS#: 122839-52-5 (HCl)

Chemical Formula: C9H11ClFNO2

Exact Mass: 183.0696

Molecular Weight: 219.64

Elemental Analysis: C, 49.22; H, 5.05; Cl, 16.14; F, 8.65; N, 6.38; O, 14.57

Price and Availability

Size Price Availability Quantity
250mg USD 250.00 2 Weeks
1g USD 450.00 2 Weeks
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Related CAS #
122839-52-5 (HCl) 51-65-0 1132-68-9; 122839-52-5
Synonym
4-Fluorophenylalanine; (S)-4-Fluorophenylalanine; L-4-Fluorophenylalanine; (S) 4 Fluorophenylalanine.
IUPAC/Chemical Name
(2S)-2-Amino-3-(4-fluorophenyl)propanoic acid hydrochloride
InChi Key
ZDECBCKSULAIGP-QRPNPIFTSA-N
InChi Code
InChI=1S/C9H10FNO2.ClH/c10-7-3-1-6(2-4-7)5-8(11)9(12)13;/h1-4,8H,5,11H2,(H,12,13);1H/t8-;/m0./s1
SMILES Code
O=C(O)[C@@H](N)CC1=CC=C(F)C=C1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 219.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wheatley DN. Temperature and the progression of HeLa S-3 cells from G2 into mitosis in the presence and absence of the amino acid analogue, para-fluorophenylalanine. Cytobios. 1977;18(69):37-50. PubMed PMID: 608351. 2: Wheatley tdn, henderson JY. Recovery of HeLa cells from inhibited entry into mitosis induced by p-fluorophenylalanine. Exp Cell Res. 1975 Apr;92(1):211-20. PubMed PMID: 1132428. 3: Sunkara PS, Chakroborty BM, Wright DA, Rao PN. Chromosome condensing ability of mitotic proteins diminished by the substitution of phenylalanine with parafluorophenylalanine. Eur J Cell Biol. 1981 Feb;23(2):312-6. PubMed PMID: 7193581. 4: Rao PN, Sunkara PS. Correlation between the high rate of protein synthesis during mitosis and the absence of G1 period in V79-8 cells. Exp Cell Res. 1980 Feb;125(2):507-11. PubMed PMID: 7353608. 5: Inglis MS, Wheatley DN. Reversible retention of synchronized HeLa cells in G2 of the mammalian cell cycle. Cell Biol Int Rep. 1979 Dec;3(9):739-46. PubMed PMID: 509545. 6: Rao PN. The molecular basis of drug-induced G2 arrest in mammalian cells. Mol Cell Biochem. 1980 Jan 16;29(1):47-57. Review. PubMed PMID: 6154231. 7: Wheatley DN, Inglis MS. Amino acid analogues and the progression of HeLa cells into mitosis. I. Pre-mitotic arrest and thermosensitivity of HeLa cells in relation to the uptake and incorporation of various amino acid analogues. Exp Cell Res. 1977 Jun;107(1):191-9. PubMed PMID: 140806. 8: Brook JD, Chandley AC. Testing for the chemical induction of aneuploidy in the male mouse. Mutat Res. 1986 Apr;164(2):117-25. PubMed PMID: 3960041. 9: Parry JM, Sharp D, Parry EM. Detection of mitotic and meiotic aneuploidy in the yeast Saccharomyces cerevisiae. Environ Health Perspect. 1979 Aug;31:97-111. PubMed PMID: 387403; PubMed Central PMCID: PMC1637641. 10: Wheatley DN, Henderson JY. P-fluorophenylalanine and 'division-related proteins'. Nature. 1974 Feb 1;247(5439):281-3. PubMed PMID: 4818361. 11: Andersen O, Rønne M, Nordberg GF. Effects of inorganic metal salts on chromosome length in human lymphocytes. Hereditas. 1983;98(1):65-70. PubMed PMID: 6853219. 12: Babudri N, Morpurgo G. Frequency of spontaneous and induced recessive mutations in a diploid strain of Aspergillus nidulans. Mutat Res. 1990 Jun;230(2):187-95. PubMed PMID: 2197553. 13: Jouanneau JP. Protein synthesis requirement for the cytokinin effect upon tobacco cell division. Exp Cell Res. 1975 Mar 1;91(1):184-90. PubMed PMID: 1132416. 14: Andersen O, Rønne M. Effect of histidinol and parafluorophenylalanine on metaphase chromosome structure in human lymphoid cells. Hereditas. 1978;88(2):197-201. PubMed PMID: 689893. 15: Albertini S. Reevaluation of the 9 compounds reported conclusive positive in yeast Saccharomyces cerevisiae aneuploidy test systems by the Gene-Tox Program using strain D61.M of Saccharomyces cerevisiae. Mutat Res. 1991 Jun;260(2):165-80. PubMed PMID: 2046697. 16: Sisken JE, Wilkes E. The time of synthesis and the conservation of mitosis-related proteins in cultured human amnion cells. J Cell Biol. 1967 Jul;34(1):97-110. PubMed PMID: 6033548; PubMed Central PMCID: PMC2107237. 17: Singh M, Sinha U. Chloral hydrate induced haploidization in Aspergillus nidulans. Experientia. 1976 Sep 15;32(9):1144-5. PubMed PMID: 786720.