VA-K-14 is a TSHR antagonist (thyroid-stimulating hormone receptor). VA-K-14 had an IC50 = 12.32 μM. VA-K-14 can specifically inhibit TSHR signaling. It was identified through high - throughput screening (HTS) using a transcription - based TSH - inhibition bioassay. In the assay, it showed significant inhibition of TSH - induced activation of the TSHR - expressing CHO cells. Its IC₅₀ value was 12.3 μM, indicating its potency in inhibiting TSHR - mediated responses.
MedKoo Cat#: 561052
Name: VA-K-14 HCl
CAS#: 1171341-19-7 (HCl)
Chemical Formula: C18H16ClN3S
Exact Mass: 0.0000
Molecular Weight: 341.86
Elemental Analysis: C, 63.24; H, 4.72; Cl, 10.37; N, 12.29; S, 9.38
The following data is based on the product molecular weight 341.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
