WNK-IN-B, also known as Compound B, is a Wnk signalling inhibitor. WNK-IN-B is a cell-permeable diaminoacridine derivative that targets the CCT domain of SPAK and OSR1 via reversible binding It has been shown to selectively suppress hypotonic shock-induced WNK signaling pathway activation in mpkDCT and MOVAS (100 µM) cultures without affecting p38 MAPK phosphorylation.
MedKoo Cat#: 561039
Name: WNK-IN-B
CAS#: 332922-63-1
Chemical Formula: C20H19N3O2
Exact Mass: 333.1477
Molecular Weight: 333.39
Elemental Analysis: C, 72.05; H, 5.74; N, 12.60; O, 9.60
The following data is based on the product molecular weight 333.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |