MedKoo Cat#: 412714 | Name: (R)-FTY720-OMe
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.

Chemical Structure

(R)-FTY720-OMe
(R)-FTY720-OMe
CAS#1382486-90-9

Theoretical Analysis

MedKoo Cat#: 412714

Name: (R)-FTY720-OMe

CAS#: 1382486-90-9

Chemical Formula: C20H35NO2

Exact Mass: 321.2668

Molecular Weight: 321.51

Elemental Analysis: C, 74.72; H, 10.97; N, 4.36; O, 9.95

Price and Availability

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1g USD 450.00 2 Weeks
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Related CAS #
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Synonym
(R)-FTY720-OMe; (R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol
IUPAC/Chemical Name
(R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol
InChi Key
YEYZALQTJCVXIJ-HXUWFJFHSA-N
InChi Code
InChI=1S/C20H35NO2/c1-3-4-5-6-7-8-9-18-10-12-19(13-11-18)14-15-20(21,16-22)17-23-2/h10-13,22H,3-9,14-17,21H2,1-2H3/t20-/m1/s1
SMILES Code
CCCCCCCCC1=CC=C(CC[C@@](COC)(N)CO)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 321.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Watson, D.G., Tonelli, F., Alossaimi, M., Williamson, L., Chan, E., Gorshkova, I., Berdyshev, E., Bittman, R., Pyne, N.J., Pyne, S. (2013). The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cell Signal 25:1011-1017. [PubMed] 2. Tonelli, F., Alossaimi, M., Williamson, L., Tate, R.J., Watson, D.G., Chan, E., Bittman, R., Pyne, N.J., Pyne, S. (2013). The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism. Br J Pharmacol. 168(6):1497-505. [PubMed] 3. Lim, K.G., Sun, C., Bittman, R., Pyne, N.J., Pyne, S. (2011). (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cell Signal 23:1590-5. [PubMed]