MedKoo Cat#: 561004 | Name: APS-2-79 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

APS-2-79 HCl is a modulator of KSR-dependent MAPK signaling, antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK (mitogen-activated protein kinase).

Chemical Structure

APS-2-79 HCl
APS-2-79 HCl
CAS#2002381-31-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 561004

Name: APS-2-79 HCl

CAS#: 2002381-31-7 (HCl)

Chemical Formula: C23H22ClN3O3

Exact Mass: 0.0000

Molecular Weight: 423.90

Elemental Analysis: C, 65.17; H, 5.23; Cl, 8.36; N, 9.91; O, 11.32

Price and Availability

Size Price Availability Quantity
50mg USD 250.00 2 Weeks
100mg USD 450.00 2 Weeks
200mg USD 750.00 2 Weeks
500mg USD 1,550.00 2 Weeks
1g USD 2,550.00 2 Weeks
2g USD 4,650.00 2 Weeks
5g USD 6,950.00 2 Weeks
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Synonym
APS-2-79 HCl; APS2-79 HCl; APS 2-79 HCl; APS-279 HCl; APS279 HCl; APS 279 HCl;
IUPAC/Chemical Name
6,7-Dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine Hydrochloride
InChi Key
LIXKSHWZJNNZHG-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H21N3O3.ClH/c1-15-11-17(29-16-7-5-4-6-8-16)9-10-19(15)26-23-18-12-21(27-2)22(28-3)13-20(18)24-14-25-23;/h4-14H,1-3H3,(H,24,25,26);1H
SMILES Code
CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=C4C=C(OC)C(OC)=CC4=NC=N3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 423.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Neilsen BK, Frodyma DE, Lewis RE, Fisher KW. KSR as a therapeutic target for Ras-dependent cancers. Expert Opin Ther Targets. 2017 May;21(5):499-509. doi: 10.1080/14728222.2017.1311325. Epub 2017 Apr 7. Review. PubMed PMID: 28333549; PubMed Central PMCID: PMC5490495. 2: KSR Mutations Guide Development of RAS Pathway Antagonists. Cancer Discov. 2016 Oct;6(10):1079. Epub 2016 Sep 2. PubMed PMID: 27591198.