Synonym
(BrMT)2, 6-Bromo-2-mercaptotryptamine dimer.
IUPAC/Chemical Name
2,2'-Dithiobis[6-bromo-1H-indole-3-ethanamine
InChi Key
UEAVXFIIBASFEK-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H20Br2N4S2/c21-11-1-3-13-15(5-7-23)19(25-17(13)9-11)27-28-20-16(6-8-24)14-4-2-12(22)10-18(14)26-20/h1-4,9-10,25-26H,5-8,23-24H2
SMILES Code
NCCC1=C(SSC(N2)=C(CCN)C3=C2C=C(Br)C=C3)NC4=C1C=CC(Br)=C4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
540.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gao D, Sand R, Fu H, Sharmin N, Gallin WJ, Hall DG. Synthesis of the non-peptidic snail toxin 6-bromo-2-mercaptotryptamine dimer (BrMT)(2), its lower and higher thio homologs and their ability to modulate potassium ion channels. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5503-6. doi: 10.1016/j.bmcl.2013.08.070. Epub 2013 Aug 22. PubMed PMID: 24021461.
2: Ahn YO, Kim SH, Lee J, Kim H, Lee HS, Kwak SS. Three Brassica rapa metallothionein genes are differentially regulated under various stress conditions. Mol Biol Rep. 2012 Mar;39(3):2059-67. doi: 10.1007/s11033-011-0953-5. Epub 2011 Jun 4. PubMed PMID: 21643753.
3: Sack JT, Aldrich RW. Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathway. J Gen Physiol. 2006 Jul;128(1):119-32. PubMed PMID: 16801385; PubMed Central PMCID: PMC2151558.
4: Wolters AM, Jayawickrama DA, Sweedler JV. Comparative analysis of a neurotoxin from Calliostoma canaliculatum by on-line capillary isotachophoresis/1H NMR and diffusion 1H NMR. J Nat Prod. 2005 Feb;68(2):162-7. PubMed PMID: 15730236.
5: Sack JT, Aldrich RW, Gilly WF. A gastropod toxin selectively slows early transitions in the Shaker K channel's activation pathway. J Gen Physiol. 2004 Jun;123(6):685-96. Epub 2004 May 17. PubMed PMID: 15148327; PubMed Central PMCID: PMC2234574.
6: Kelley WP, Wolters AM, Sack JT, Jockusch RA, Jurchen JC, Williams ER, Sweedler JV, Gilly WF. Characterization of a novel gastropod toxin (6-bromo-2-mercaptotryptamine) that inhibits shaker K channel activity. J Biol Chem. 2003 Sep 12;278(37):34934-42. Epub 2003 Jun 18. PubMed PMID: 12815055.
