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MedKoo Cat#: 540148 | Name: D-Galactosamine HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

D-Galactosamine HCl is a galactose-derived hexosaine sugar and component of FSH and LH. It is used to induce endotoxic shock.

Chemical Structure

D-Galactosamine HCl
D-Galactosamine HCl
CAS#1772-03-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 540148

Name: D-Galactosamine HCl

CAS#: 1772-03-8 (HCl)

Chemical Formula: C6H14ClNO5

Exact Mass: 215.0561

Molecular Weight: 215.63

Elemental Analysis: C, 33.42; H, 6.54; Cl, 16.44; N, 6.50; O, 37.10

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 450.00 2 Weeks
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Related CAS #
7535-00-4 (free base) 1772-03-8 (HCl)
Synonym
D-Galactosamine HCl; Chondrosamine HCl; D-Chondrosamine hydrochloride;
IUPAC/Chemical Name
(2R,3R,4R,5R)-2-amino-3,4,5,6-tetrahydroxyhexanal hydrochloride
InChi Key
CBOJBBMQJBVCMW-NQZVPSPJSA-N
InChi Code
InChI=1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
SMILES Code
Cl.OC[C@H]([C@@H]([C@@H]([C@H](C=O)N)O)O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 215.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hossen MJ, Kim MY, Kim JH, Cho JY. AP-1-Targeted Inhibition of Macrophage Function and Lipopolysaccharide/D-Galactosamine-Induced Hepatitis by Phyllanthus acidus Methanolic Extract. Am J Chin Med. 2015;43(6):1137-58. doi: 10.1142/S0192415X15500652. Epub 2015 Sep 17. PubMed PMID: 26381032. 2: Deshpande UR, Joseph LJ, Samuel AM. Hepatobiliary clearance of labelled mebrofenin in normal and D-galactosamine HCl-induced hepatitis rats and the protective effect of turmeric extract. Indian J Physiol Pharmacol. 2003 Jul;47(3):332-6. PubMed PMID: 14723320. 3: Lesch R, Deus B, Reutter W. The appearance of D-galactosamine-induced hepatitis and generalized edema in adrenalectomized rats. Beitr Pathol. 1975 Sep;156(1):32-45. PubMed PMID: 1180818. 4: Lapis K, Schaff Z. Ultrastructural studies on D-galactosamine-HCl-induced liver injury in mice. Morphol Igazsagugyi Orv Sz. 1973 Aug;13(4):276-88. PubMed PMID: 4724880. 5: Suzuki Y, Tabata R, Okawa KI. Effect of D-galactosamine-HCl on the pulmonary surfactant in the rat. Exp Mol Pathol. 1978 Jun;28(3):349-59. PubMed PMID: 580606. 6: Zuyderhoudt FM, Jörning GG, De Haan JG, Samson G, Van Gool J. Rat liver storage iron and plasma ferritin during D-galactosamine-HCl-induced hepatitis. Clin Sci (Lond). 1980 Apr;58(4):321-5. PubMed PMID: 7379457. 7: Haug H, Klinge O, Telander R, Rowek H. [Effect of D-galactosamine-HCl on the principal chain enzymes in the liver tissue and on plasma enzymes and metabolites in the male rat]. Verh Dtsch Ges Inn Med. 1976;82 Pt 1:378-83. German. PubMed PMID: 1029215. 8: Kröger H, Grätz R. Induction of tyrosine aminotransferase under the influence of D-galactosamine. Int J Biochem. 1984;16(6):703-5. PubMed PMID: 6147282. 9: Boelcke G, Poser W, Michelssen A, Erdmann WD. [Cholinesterase activity in rabbit plasma after severe hepatic damage caused by D-galactosamine-HCl]. Arch Toxikol. 1971;28(3):192-201. German. PubMed PMID: 5126462. 10: Kröger H, Grätz R, Museteanu C, Haase J. The influence of nicotinamide, tryptophan, and methionine upon galactosamine-induced effects in the liver. Arzneimittelforschung. 1981;31(6):987-93. PubMed PMID: 6455126. 11: Koosha M, Abai MR, Abolhasani M, Charedar S, Basseri HR. Lectin Activity in Gut Extract of Culex pipiens. J Arthropod Borne Dis. 2013 Apr 10;7(1):23-30. Print 2013. PubMed PMID: 23785692; PubMed Central PMCID: PMC3684494. 12: Yu T, Rhee MH, Lee J, Kim SH, Yang Y, Kim HG, Kim Y, Kim C, Kwak YS, Kim JH, Cho JY. Ginsenoside Rc from Korean Red Ginseng (Panax ginseng C.A. Meyer) Attenuates Inflammatory Symptoms of Gastritis, Hepatitis and Arthritis. Am J Chin Med. 2016;44(3):595-615. doi: 10.1142/S0192415X16500336. Epub 2016 Apr 24. PubMed PMID: 27109153. 13: Schaff Z, Lapis K, Szendröi M. D-galactosamine-induced liver injury in immunosuppressed mice. Acta Morphol Hung. 1984;32(1):67-72. PubMed PMID: 6087623. 14: Fukuda T, Mogami A, Tanaka H, Yoshikawa T, Hisadome M, Komatsu H. Y-40138, a multiple cytokine production modulator, protects against D-galactosamine and lipopolysaccharide-induced hepatitis. Life Sci. 2006 Jul 24;79(9):822-7. Epub 2006 Mar 28. PubMed PMID: 16626762. 15: Yamaguchi T, Kashige N, Matsumoto S, Satoh K, Yasuda M, Watanabe K. A carbon-centered radical as a reaction species in the DNA strand-breakage by D-glucosamine. Biol Pharm Bull. 1998 Mar;21(3):205-9. PubMed PMID: 9556145. 16: Skrypal' IH, Tokovenko IP, Malynovs'ka LP. [Soluble and semisoluble lectins from mollicutes and their possible functions]. Mikrobiol Z. 1993 Jun-Aug;55(4):20-4. Ukrainian. PubMed PMID: 8220826. 17: Abbey M, Calvert GD. D-galactosamine induced hepatitis in the rabbit: effect on lecithin:cholesterol acyltransferase activity, plasma lipid transfer protein activity and high density lipoproteins. Comp Biochem Physiol B. 1986;85(3):659-67. PubMed PMID: 3791965. 18: Schulzke JD, Tauber R, Reutter W. Incorporation of non-acetylated hexosamines into plasma membrane glycoproteins of liver cells after galactosamine injection. Biol Chem Hoppe Seyler. 1988 Sep;369(9):957-64. PubMed PMID: 3228492. 19: Ito I, Muro H, Kosugi I, Shirasawa H. Alterations in Fc receptor activity in sinusoidal endothelial cells and Kupffer cells during D-galactosamine (GalN)-induced liver injury in rats. A histological study. Virchows Arch B Cell Pathol Incl Mol Pathol. 1990;58(6):417-25. PubMed PMID: 1972824. 20: Ryan CJ, Aslam M, Courtney JM. Transference of hepatic coma to normal rats from galactosamine treated donors by reverse plasma exchange. Biomater Artif Cells Artif Organs. 1990;18(4):477-82. PubMed PMID: 2285809.