MedKoo Cat#: 526400 | Name: UMK57
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

UMK57 is a novel inhibitor of chromosomal instability, potentiating MCAK in vivo and transiently suppressing chromosome mis-segregation in CIN cancer cells.

Chemical Structure

UMK57
UMK57
CAS#342595-74-8

Theoretical Analysis

MedKoo Cat#: 526400

Name: UMK57

CAS#: 342595-74-8

Chemical Formula: C17H17N3S

Exact Mass: 295.1143

Molecular Weight: 295.40

Elemental Analysis: C, 69.12; H, 5.80; N, 14.22; S, 10.85

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 Weeks
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,650.00 2 Weeks
500mg USD 2,950.00 2 Weeks
1g USD 4,850.00 2 Weeks
2g USD 7,650.00 2 Weeks
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Related CAS #
No Data
Synonym
UMK57; UMK-57; UMK 57
IUPAC/Chemical Name
4-Pyrrolidin-1-yl-5-p-tolyl-thieno[2,3-d]pyrimidine
InChi Key
VOAWQTDHSSKEKA-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H17N3S/c1-12-4-6-13(7-5-12)14-10-21-17-15(14)16(18-11-19-17)20-8-2-3-9-20/h4-7,10-11H,2-3,8-9H2,1H3
SMILES Code
CC1=CC=C(C2=CSC3=NC=NC(N4CCCC4)=C32)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 295.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Orr B, Talje L, Liu Z, Kwok BH, Compton DA. Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells. Cell Rep. 2016 Nov 8;17(7):1755-1763. doi: 10.1016/j.celrep.2016.10.030. PubMed PMID: 27829147; PubMed Central PMCID: PMC5130158.