RSV 604 | CAS# 676128-63-5 | Nucleocapsid protein inhibitor

MedKoo Cat#: 529114 | Name: RSV 604

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RSV 604 is a nucleocapsid protein inhibitor potentially for the treatment of respiratory syncytial virus infections.

Chemical Structure

RSV 604

CAS#676128-63-5

Theoretical Analysis

MedKoo Cat#: 529114

Name: RSV 604

CAS#: 676128-63-5

Chemical Formula: C22H17FN4O2

Exact Mass: 388.1336

Molecular Weight: 388.40

Elemental Analysis: C, 68.03; H, 4.41; F, 4.89; N, 14.43; O, 8.24

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 205.00
5mg	USD 375.00
10mg	USD 600.00
25mg	USD 1,150.00

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Related CAS #

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Synonym

RSV-604; A-60444; RSV604; A60444; RSV 604; A 60444

IUPAC/Chemical Name

(S)-1-(2-fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea

InChi Key

MTPVBMVUENFFLL-HXUWFJFHSA-N

InChi Code

InChI=1S/C22H17FN4O2/c23-16-11-5-7-13-18(16)25-22(29)27-20-21(28)24-17-12-6-4-10-15(17)19(26-20)14-8-2-1-3-9-14/h1-13,20H,(H,24,28)(H2,25,27,29)/t20-/m1/s1

SMILES Code

O=C(NC1=CC=CC=C1F)N[C@@H]2C(NC3=CC=CC=C3C(C4=CC=CC=C4)=N2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 388.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Henderson EA, Alber DG, Baxter RC, Bithell SK, Budworth J, Carter MC, Chubb A, Cockerill GS, Dowdell VC, Fraser IJ, Harris RA, Keegan SJ, Kelsey RD, Lumley JA, Stables JN, Weerasekera N, Wilson LJ, Powell KL. 1,4-benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate. J Med Chem. 2007 Apr 5;50(7):1685-92. PubMed PMID: 17341059. 2: El Omari K, Scott K, Dhaliwal B, Ren J, Abrescia NG, Budworth J, Lockyer M, Powell KL, Hawkins AR, Stammers DK. Crystallization and preliminary X-ray analysis of the human respiratory syncytial virus nucleocapsid protein. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):1019-23. doi: 10.1107/S1744309108031059. PubMed PMID: 18997331; PubMed Central PMCID: PMC2581706. 3: Challa S, Scott AD, Yuzhakov O, Zhou Y, Tiong-Yip CL, Gao N, Thresher J, Yu Q. Mechanism of action for respiratory syncytial virus inhibitor RSV604. Antimicrob Agents Chemother. 2015 Feb;59(2):1080-7. doi: 10.1128/AAC.04119-14. PubMed PMID: 25451060; PubMed Central PMCID: PMC4335855. 4: Nokes JD, Cane PA. New strategies for control of respiratory syncytial virus infection. Curr Opin Infect Dis. 2008 Dec;21(6):639-43. doi: 10.1097/QCO.0b013e3283184245. Review. PubMed PMID: 18978532. 5: Chapman J, Abbott E, Alber DG, Baxter RC, Bithell SK, Henderson EA, Carter MC, Chambers P, Chubb A, Cockerill GS, Collins PL, Dowdell VC, Keegan SJ, Kelsey RD, Lockyer MJ, Luongo C, Najarro P, Pickles RJ, Simmonds M, Taylor D, Tyms S, Wilson LJ, Powell KL. RSV604, a novel inhibitor of respiratory syncytial virus replication. Antimicrob Agents Chemother. 2007 Sep;51(9):3346-53. PubMed PMID: 17576833; PubMed Central PMCID: PMC2043207.