RS-25344 HCl | CAS#152815-28-6 |152814-89-6 | PDE 4 inhibitor

MedKoo Cat#: 532586 | Name: RS-25344 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RS-25344 HCl is a potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). It inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.

Chemical Structure

RS-25344 HCl

CAS#152815-28-6(RS-25344 HCl); 152814-89-6 (RS-25344).

Theoretical Analysis

MedKoo Cat#: 532586

Name: RS-25344 HCl

CAS#: 152815-28-6(RS-25344 HCl); 152814-89-6 (RS-25344).

Chemical Formula: C19H18ClN5O4

Exact Mass:

Molecular Weight: 415.83

Elemental Analysis: C, 54.88; H, 4.36; Cl, 8.53; N, 16.84; O, 15.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

152815-28-6(RS-25344 HCl); 152814-89-6 (RS-25344).

Synonym

RS-25344 HCl; RS 25344 HCl; RS25344 HCl.

IUPAC/Chemical Name

1-(3-Nitrophenyl)-3-(4-pyridinylmethyl)-pyrido[2,3-d]pyrimidine-2,3-(1H,3H)-dione hydrochloride

InChi Key

NYZOOMDEQVWPGI-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H17N5O4.ClH/c25-19-22(16-4-1-5-17(11-16)23(26)27)18-15(3-2-8-21-18)13-24(19,28)12-14-6-9-20-10-7-14;/h1-7,9-11,21H,8,12-13H2;1H

SMILES Code

1-(3-nitrophenyl)-2-oxo-3-(pyridin-4-ylmethyl)-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine 3-oxide hydrochloride

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 415.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Bajpai et al (2006) AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa. Biol.Reprod. 74 109. PMID: 16177223. 2. Alvarez et al (1995) Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3. Mol.Pharmacol. 48 616. PMID: 7476886.