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MedKoo Cat#: 526392 | Name: MMPP

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MMPP is a novel potent inhibitor of pro-inflammatory responses by inhibiting in vitro STAT3 activation and its downstream signalling in murine macrophages and human synoviocytes from patients with RA.

Chemical Structure

MMPP
CAS#1895957-18-2

Theoretical Analysis

MedKoo Cat#: 526392

Name: MMPP

CAS#: 1895957-18-2

Chemical Formula: C17H18O3

Exact Mass: 270.1256

Molecular Weight: 270.33

Elemental Analysis: C, 75.53; H, 6.71; O, 17.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MMPP
IUPAC/Chemical Name
(E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl)phenol
InChi Key
YXLMKJHTTWBHRD-HWKANZROSA-N
InChi Code
InChI=1S/C17H18O3/c1-19-15-9-6-13(7-10-15)4-3-5-14-8-11-16(18)17(12-14)20-2/h3,5-12,18H,4H2,1-2H3/b5-3+
SMILES Code
OC1=CC=C(/C=C/CC2=CC=C(OC)C=C2)C=C1OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 270.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nagasawa S, Sasano Y, Iwabuchi Y. Catalytic Oxygenative Allylic Transposition of Alkenes into Enones Realized by an Azaadamantane-Type Oxoammonium Salt Catalyst. Chemistry. 2017 Jun 3. doi: 10.1002/chem.201702512. [Epub ahead of print] PubMed PMID: 28577334. 2: Park CW, Song YS, Lee HP, Hong JT, Yoon DY. (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol induces apoptosis in HeLa cervical cancer cells via the extrinsic apoptotic pathway. J Microbiol Biotechnol. 2017 May 17. doi: 10.4014/jmb.1703.03060. [Epub ahead of print] PubMed PMID: 28511296. 3: Zheng J, Son DJ, Lee HL, Lee HP, Kim TH, Joo JH, Ham YW, Kim WJ, Jung JK, Han SB, Hong JT. (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol suppresses ovarian cancer cell growth via inhibition of ERK and STAT3. Mol Carcinog. 2017 Mar 9. doi: 10.1002/mc.22648. [Epub ahead of print] PubMed PMID: 28277616. 4: Son DJ, Kim DH, Nah SS, Park MH, Lee HP, Han SB, Venkatareddy U, Gann B, Rodriguez K, Burt SR, Ham YW, Jung YY, Hong JT. Novel synthetic (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol inhibits arthritis by targeting signal transducer and activator of transcription 3. Sci Rep. 2016 Nov 15;6:36852. doi: 10.1038/srep36852. PubMed PMID: 27845373; PubMed Central PMCID: PMC5109275. 5: Liu H, Mei X, Zhang Z, Sun J. Mini-midvastus versus mini-medial parapatellar approach in simultaneous bilateral total knee arthroplasty with 24-month follow-up. Acta Orthop Traumatol Turc. 2015;49(6):586-92. doi: 10.3944/AOTT.2015.15.0078. PubMed PMID: 26511683. 6: Temperini A, Curini M, Rosati O, Minuti L. Magnesium bis(monoperoxyphthalate) hexahydrate as mild and efficient oxidant for the synthesis of selenones. Beilstein J Org Chem. 2014 Jun 2;10:1267-71. doi: 10.3762/bjoc.10.127. eCollection 2014. PubMed PMID: 24991278; PubMed Central PMCID: PMC4077369. 7: Navarrete A, Flores-Machorro FX, Téllez-Ballesteros RI, Alfaro-Romero A, Balderas JL, Reyes A. Study on action mechanism of 1-(4-methoxy-2-methylphenyl)piperazine (MMPP) in acquisition, formation, and consolidation of memory in mice. Drug Dev Res. 2014 Mar;75(2):59-67. doi: 10.1002/ddr.21094. Epub 2013 Aug 2. PubMed PMID: 24648132. 8: Manfredini R, Fabbian F, Manfredini F, Salmi R, Gallerani M, Bossone E. Chronobiology in aortic diseases - "is this really a random phenomenon?". Prog Cardiovasc Dis. 2013 Jul-Aug;56(1):116-24. doi: 10.1016/j.pcad.2013.04.001. Epub 2013 May 23. Review. PubMed PMID: 23993245. 9: Cuesta-Vargas AI, Buchan J, Arroyo-Morales M. A multimodal physiotherapy programme plus deep water running for improving cancer-related fatigue and quality of life in breast cancer survivors. Eur J Cancer Care (Engl). 2014 Jan;23(1):15-21. doi: 10.1111/ecc.12114. Epub 2013 Aug 16. PubMed PMID: 23947581. 10: Heekin RD, Fokin AA. Mini-midvastus versus mini-medial parapatellar approach for minimally invasive total knee arthroplasty: outcomes pendulum is at equilibrium. J Arthroplasty. 2014 Feb;29(2):339-42. doi: 10.1016/j.arth.2013.05.016. Epub 2013 Jun 19. PubMed PMID: 23790343. 11: Thayakaran R, Ramesh NI. Markov modulated Poisson process models incorporating covariates for rainfall intensity. Water Sci Technol. 2013;67(8):1786-92. doi: 10.2166/wst.2013.056. PubMed PMID: 23579834. 12: Salvador JA, Moreira VM, Pinto RM, Leal AS, Paixão JA. Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives. Beilstein J Org Chem. 2012;8:164-9. doi: 10.3762/bjoc.8.17. Epub 2012 Jan 30. PubMed PMID: 22423283; PubMed Central PMCID: PMC3302076. 13: Horejsh D, Kampf G. Efficacy of three surface disinfectants against spores of Clostridium difficile ribotype 027. Int J Hyg Environ Health. 2011 Mar;214(2):172-4. doi: 10.1016/j.ijheh.2010.10.004. Epub 2010 Dec 4. PubMed PMID: 21134785. 14: Toporisic R, Mlakar A, Hvala J, Prislan I, Zupancic-Kralj L. Identification of new impurities of enalapril maleate on oxidation in the presence of magnesium monoperoxyphthalate. J Pharm Biomed Anal. 2010 Jun 5;52(2):294-9. doi: 10.1016/j.jpba.2009.12.018. Epub 2009 Dec 29. PubMed PMID: 20122808. 15: Jäger M, Kiel A, Herten DP, Hamprecht FA. Analysis of single-molecule fluorescence spectroscopic data with a Markov-modulated Poisson process. Chemphyschem. 2009 Oct 5;10(14):2486-95. doi: 10.1002/cphc.200900331. PubMed PMID: 19644999. 16: Inami K, Okazawa M, Mochizuki M. Mutagenicity of aromatic amines and amides with chemical models for cytochrome P450 in Ames assay. Toxicol In Vitro. 2009 Sep;23(6):986-91. doi: 10.1016/j.tiv.2009.06.025. Epub 2009 Jun 27. PubMed PMID: 19563884. 17: Chandrasekhar V, Nagarajan L, Clérac R, Ghosh S, Senapati T, Verma S. Barrel- and crown-shaped dodecanuclear copper(II) cages built from phosphonate, pyrazole, and hydroxide ligands. Inorg Chem. 2008 Jun 16;47(12):5347-54. doi: 10.1021/ic800509f. Epub 2008 May 17. PubMed PMID: 18484717. 18: Pèpe G, Courcambeck J, Perbost R, Jouanna P, Halfon P. Prediction of HIV-1 protease inhibitor resistance by Molecular Modeling Protocols (MMPs) using GenMol software. Eur J Med Chem. 2008 Nov;43(11):2518-34. doi: 10.1016/j.ejmech.2008.02.046. Epub 2008 Mar 14. PubMed PMID: 18455274. 19: Chandrasekhar V, Azhakar R, Senapati T, Thilagar P, Ghosh S, Verma S, Boomishankar R, Steiner A, Kögerler P. Synthesis, structure, magnetism and nuclease activity of tetranuclear copper(II) phosphonates containing ancillary 2,2'-bipyridine or 1,10-phenanthroline ligands. Dalton Trans. 2008 Mar 7;(9):1150-60. doi: 10.1039/b712876b. Epub 2008 Jan 7. PubMed PMID: 18283376. 20: Chandrasekhar V, Nagarajan L, Clérac R, Ghosh S, Verma S. A distorted cubic tetranuclear copper(II) phosphonate cage with a double-four-ring-type core. Inorg Chem. 2008 Feb 4;47(3):1067-73. doi: 10.1021/ic701948g. Epub 2008 Jan 10. PubMed PMID: 18183972.

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