Syringin | CAS#118-34-3 | phenylpropanoid glycoside

MedKoo Cat#: 329676 | Name: Syringin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Syringin is a phenylpropanoid glycoside first isolated from A. senticosus. Syringin attenuates insulin resistance via adiponectin-mediated suppression of low-grade chronic inflammation and ER stress in high-fat diet-fed mice. Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy.

Chemical Structure

Syringin

CAS#118-34-3

Theoretical Analysis

MedKoo Cat#: 329676

Name: Syringin

CAS#: 118-34-3

Chemical Formula: C17H24O9

Exact Mass: 372.1420

Molecular Weight: 372.37

Elemental Analysis: C, 54.83; H, 6.50; O, 38.67

Price and Availability

Size	Price	Availability
10mg	USD 320.00	2 Weeks
25mg	USD 550.00	2 Weeks
50mg	USD 850.00	2 Weeks

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Related CAS #

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Synonym

Syringin; Eleutheroside B; NSC 287441; NSC-287441; NSC287441.

IUPAC/Chemical Name

(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-((E)-3-hydroxyprop-1-en-1-yl)-2,6-dimethoxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol

InChi Key

QJVXKWHHAMZTBY-GCPOEHJPSA-N

InChi Code

InChI=1S/C17H24O9/c1-23-10-6-9(4-3-5-18)7-11(24-2)16(10)26-17-15(22)14(21)13(20)12(8-19)25-17/h3-4,6-7,12-15,17-22H,5,8H2,1-2H3/b4-3+/t12-,13-,14+,15-,17+/m1/s1

SMILES Code

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=C(OC)C=C(/C=C/CO)C=C2OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 372.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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PMID: 38613069; PMCID: PMC11013749. 11: Dong X, Chen Q, Chi W, Qiu Z, Qiu Y. A Metabolomics Study of the Effects of Eleutheroside B on Glucose and Lipid Metabolism in a Zebrafish Diabetes Model. Molecules. 2024 Mar 29;29(7):1545. doi: 10.3390/molecules29071545. PMID: 38611823; PMCID: PMC11013803. 12: Zhao Y, Luo X, Hu J, Panga MJ, Appiah C, Du Z, Zhu L, Retyunskiy V, Gao X, Ma B, Zhang Q. Syringin alleviates bisphenol A-induced spermatogenic defects and testicular injury by suppressing oxidative stress and inflammation in male zebrafish. Int Immunopharmacol. 2024 Apr 20;131:111830. doi: 10.1016/j.intimp.2024.111830. Epub 2024 Mar 22. PMID: 38520788. 13: Ai J, Yu JF, Wang J, Wang XX, Wang ZZ. [Optimization of processing technology of bark of Ilicis Rotundae Cortex based on quality by design concept]. Zhongguo Zhong Yao Za Zhi. 2024 Jan;49(2):403-411. Chinese. doi: 10.19540/j.cnki.cjcmm.20231116.301. PMID: 38403316. 14: Cao XT, Wu BY, Chen J. [Eleutheroside B induces apoptosis and autophagy of lung cancer cells by regulating PI3K/Akt/mTOR pathway]. Zhongguo Zhong Yao Za Zhi. 2023 Dec;48(24):6693-6701. Chinese. doi: 10.19540/j.cnki.cjcmm.20230804.401. PMID: 38212029. 15: Hasan MM, Islam ME, Hossain MS, Akter M, Rahman MAA, Kazi M, Khan S, Parvin MS. Unveiling the therapeutic potential: Evaluation of anti-inflammatory and antineoplastic activity of Magnolia champaca Linn's stem bark isolate through molecular docking insights. Heliyon. 2023 Dec 3;10(1):e22972. doi: 10.1016/j.heliyon.2023.e22972. PMID: 38169693; PMCID: PMC10758728. 16: Kasterova EA, Prokopyeva ES, Mudrikova AE, Kravtsova SS. Comparative Contents of Polyphenolic Compounds in Aerial Parts of Cirsium esculentum, C. serratuloides, and Ancathia igniaria (Asteraceae). Dokl Biol Sci. 2023 Oct;512(1):326-332. doi: 10.1134/S0012496623700606. Epub 2023 Dec 12. PMID: 38087022. 17: Huo C, Nguyen QN, Alishir A, Ra MJ, Jung SM, Yu JN, Gwon HJ, Kang KS, Kim KH. Global Natural Products Social (GNPS)-Based Molecular-Networking-Guided Isolation of Phenolic Compounds from Ginkgo biloba Fruits and the Identification of Estrogenic Phenolic Glycosides. Plants (Basel). 2023 Nov 25;12(23):3970. doi: 10.3390/plants12233970. PMID: 38068607; PMCID: PMC10708316. 18: Li H, Meng X, Zhang Y, Guo M, Li L. Active Components of Leontopodium alpinum Callus Culture Extract for Blue Light Damage in Human Foreskin Fibroblasts. Molecules. 2023 Oct 28;28(21):7319. doi: 10.3390/molecules28217319. PMID: 37959738; PMCID: PMC10647756. 19: R N, Kh M, Hegde SN, Begum N, Kukkupuni SK, Gowda M, Narendran P. De novo genome assembly and annotation of the medicinal plant Tinospora cordifolia (Willd.) Miers ex Hook. f. & Thom's. Funct Integr Genomics. 2023 Nov 8;23(4):330. doi: 10.1007/s10142-023-01262-2. PMID: 37935874. 20: Mao J, Tan L, Tian C, Wang W, Zhang H, Zhu Z, Li Y. Hepatoprotective effect of syringin combined with costunolide against LPS-induced acute liver injury in L-02 cells via Rac1/AKT/NF-κB signaling pathway. Aging (Albany NY). 2023 Nov 1;15(21):11994-12020. doi: 10.18632/aging.205161. Epub 2023 Nov 1. PMID: 37916984; PMCID: PMC10683587.