Synonym
Phthalylsulfathiazole, Phthalylsulfathiazole sodium, Phthalylsulfathiazole sodium salt, Phthalylsulfathiazole Na, Sulfathalidine, Phthalazol
IUPAC/Chemical Name
2-((4-(N-(thiazol-2-yl)sulfamoyl)phenyl)carbamoyl)benzoic acid
InChi Key
PBMSWVPMRUJMPE-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H13N3O5S2/c21-15(13-3-1-2-4-14(13)16(22)23)19-11-5-7-12(8-6-11)27(24,25)20-17-18-9-10-26-17/h1-10H,(H,18,20)(H,19,21)(H,22,23)
SMILES Code
O=C(O)C1=CC=CC=C1C(NC2=CC=C(S(=O)(NC3=NC=CS3)=O)C=C2)=O
Appearance
White to light yellow crystalline powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Phthalylsulfathiazole is a kind of sulfonamides used as an antibacterial drug.
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| DMSO |
60.0 |
148.73 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
403.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: FLORESTANO HJ, KENNEDY JF. Observations on the activity in vitro of succinylsulfathiazole and phthalylsulfathiazole. J Lab Clin Med. 1946 Jul;31(7):757-62. PubMed PMID: 20992878.
2: BLATT ML, PLATTNER EB, et al. Phthalylsulfathiazole in the treatment of diarrhea in children. J Pediatr. 1947 Nov;31(5):548-55. PubMed PMID: 20268814.
3: POTH EJ, WISE RI, SLATTERY MP. Penicillin-phthalylsulfathiazole antagonism. Surgery. 1946 Jul;20(1):147-9. PubMed PMID: 20992245.
4: JOHNSON CG, LORENZEN LH, MAYNE RY. Treatment of urinary tract infections with sulfathalidine (phthalylsulfathiazole). Am J Obstet Gynecol. 1948 Jul;56(1):160-6. PubMed PMID: 18869728.
5: STREICHER MH. Phthalylsulfathiazole (sulfathialidine); clinical, chemical and bacteriologic evaluations in infectious diseases of the colon. J Am Med Assoc. 1945 Dec 15;129:1080-3. PubMed PMID: 21004767.
6: KEAN BH, SCHAFFNER W, BRENNAN RW. The diarrhea of travelers. V. Prophylaxis with phthalylsulfathiazole and neomycin sulphate. JAMA. 1962 May 5;180:367-71. PubMed PMID: 14454718.
7: ASKUE WE, TUFTS E. Phthalylsulfathiazole (sulfathalidine) in the treatment of enterobiasis (pinworm infection). J Pediatr. 1954 Apr;44(4):380-5. PubMed PMID: 13152646.
8: FISCH C, SACKS HJ. High phthalylsulfathiazole (sulfathalidine) level associated with granulocytopenia; case report. Gastroenterology. 1950 Dec;16(4):782-4. PubMed PMID: 14784156.
9: PRINCIPE U, CIUTI A. [Experimental study on the effect of phthalylsulfathiazole on vascular changes in the mesentery]. Sperimentale. 1951 Dec;101(11-12):324-9. Undetermined Language. PubMed PMID: 14942631.
10: MONTERO RODRIGUEZ A. [Treatment of diarrheas in children with phthalylsulfathiazole]. Hisp Med. 1951 Nov;8(89):553-8. Undetermined Language. PubMed PMID: 14897354.
11: MONTERO RODRIGUEZ A. [Treatment of diarrhea in infants and in older children with a combination of phthalylsulfathiazole and streptomycin]. Hisp Med. 1956 Feb;13(140):89-93. Spanish. PubMed PMID: 13331427.
12: YOUNG JP Jr, COLE WH. Intraperitoneal administration of succinylsulfathiazole and phthalylsulfathiazole; their use in the prophylaxis and treatment of peritonitis. Arch Surg. 1946 Aug;53:182-9. PubMed PMID: 20994768.
13: BANKER JL, SCHMIDT EG. Urinary phenols; effect of diet and phthalylsulfathiazole on the urinary phenols of the dog. J Biol Chem. 1946 Oct;165(2):431-5. PubMed PMID: 20276106.
14: Lebduska J, Bartos J, Habrda J. [Effect of steptomycin and its combinations with phthalylsulfathiazole and sulfadimidine in gastroenteritis of calves]. Vet Med (Praha). 1972;17(11):697-704. Czech. PubMed PMID: 4633382.
15: CALHOUN WK, JENNINGS RB, BRADLEY WB. Calcium oxalate excretion and hematuria in vitamin B6-deficient rats fed phthalylsulfathiazole. J Nutr. 1959 Feb 10;67(2):237-51. PubMed PMID: 13642120.
16: [Oxyquinolin phthalylsulfathiazole combined with trimethoprim in acute pediatric shigellosis and chronic carriers]. Zhonghua Yi Xue Za Zhi. 1974 May;5:284-8. Chinese. PubMed PMID: 4211545.
17: BRIMBERG J. Phthalylsulfathiazole, a cause of ureteral obstruction. N Y State J Med. 1958 Aug 1;58(15):2573-5. PubMed PMID: 13566540.
18: Tosetti GE, Gomes RP, Nacco R, Sawada T. [Reduction of aerobic intestinal flora with the association of framycetin and phthalylsulfathiazole]. Hospital (Rio J). 1966 Nov;70(5):1407-12. Portuguese. PubMed PMID: 5301955.
19: SADUN EH, MELVIN DM, BROOKE MM, CARTER CH. A new quantitative approach to the study of anthelminthic drugs, with an evaluation of piperazine hexahydrate, phthalylsulfathiazole, and RO 2-5655/3 in the treatment of Enterobius infection. J Pediatr. 1956 Jun;48(6):754-62. PubMed PMID: 13332514.
20: CACHIN M, DOREAU JL. [The treatment of diarrhea by a combination of framycetin- and phthalylsulfathiazole]. Presse Med. 1962 Sep 8;70:1729-31. French. PubMed PMID: 13875455.
