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MedKoo Cat#: 540105 | Name: Diaveridine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diaveridine is coccidiostat and dihydrofolate reductase inhibitor. It prevents folic acid synthesis in species of Pneumocystis and induces DNA damage.

Chemical Structure

Diaveridine
CAS#5355-16-8

Theoretical Analysis

MedKoo Cat#: 540105

Name: Diaveridine

CAS#: 5355-16-8

Chemical Formula: C13H16N4O2

Exact Mass: 260.1273

Molecular Weight: 260.29

Elemental Analysis: C, 59.99; H, 6.20; N, 21.52; O, 12.29

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 weeks
5g USD 650.00 2 weeks
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Related CAS #
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Synonym
Diaveridin; Diaveridinum; Diaveridina; EGIS 5645; EGIS5645; EGIS-5645; NSC 408735; NSC408735; NSC-408735; BW 49-210; BW-49-210; BW49-210; BW49210; BW-49210; BW 49210;
IUPAC/Chemical Name
5-(3,4-dimethoxybenzyl)pyrimidine-2,4-diamine
InChi Key
LDBTVAXGKYIFHO-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H16N4O2/c1-18-10-4-3-8(6-11(10)19-2)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17)
SMILES Code
NC1=NC=C(CC2=CC=C(OC)C(OC)=C2)C(N)=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 260.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang X, Su S, Ihsan A, Huang Q, Chen D, Cheng G, Liu Z, Wang Y, Yuan Z. Acute and sub-chronic toxicity study of diaveridine in Wistar rats. Regul Toxicol Pharmacol. 2015 Oct;73(1):232-40. doi: 10.1016/j.yrtph.2015.07.010. Epub 2015 Jul 21. PubMed PMID: 26209270. 2: Wang H, Yuan B, Zeng Z, He L, Ding H, Guo C, Kong X, Wang W, Huang X. Identification and elucidation of the structure of in vivo metabolites of diaveridine in chicken. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 15;965:91-9. doi: 10.1016/j.jchromb.2014.06.010. Epub 2014 Jun 23. PubMed PMID: 24999617. 3: Wang J, Sun F, Tang S, Zhang S, Cao X. Acute, mutagenicity, teratogenicity and subchronic oral toxicity studies of diaveridine in rodents. Environ Toxicol Pharmacol. 2015 Sep;40(2):660-70. doi: 10.1016/j.etap.2015.08.022. Epub 2015 Aug 23. PubMed PMID: 26397222. 4: Kang YP, Yu J, Huh Y, Oh JH, Kwon CH, Lee SJ, Ee JW, Kim GT, Lee JG, Lee J, Park JH, Kim YS, Kwon SW. Development of high performance liquid chromatography-ultraviolet detection method for screening mebendazole, clorsulon, diaveridine, and tolfenamic acid in animal-based food samples. Drug Test Anal. 2014 Mar;6(3):246-56. doi: 10.1002/dta.1467. Epub 2013 Apr 10. PubMed PMID: 23576386. 5: Mohamed GG, Rizk MS, Zaky Frag EY. Spectrophotometric Determination of Distigmine Bromide, Cyclopentolate HCl, Diaveridine HCl and Tetrahydrozoline HCl via Charge Transfer Complex Formation with TCNQ and TCNE Reagents. Iran J Pharm Res. 2015 Summer;14(3):701-14. PubMed PMID: 26330858; PubMed Central PMCID: PMC4518098. 6: Li Y, Bu S. Determination of sulphachloropyrazine-diaveridine residues by high performance liquid chromatography in broiler edible tissues. J Vet Med Sci. 2016 Jan;77(12):1555-63. doi: 10.1292/jvms.14-0605. Epub 2015 Jul 24. PubMed PMID: 26212255; PubMed Central PMCID: PMC4710710. 7: Liu ZY, Wu Y, Sun ZL, Wan L. Characterization of in vitro metabolites of trimethoprim and diaveridine in pig liver microsomes by liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry. Biomed Chromatogr. 2012 Sep;26(9):1101-8. doi: 10.1002/bmc.1754. Epub 2011 Dec 12. PubMed PMID: 22161732. 8: Yang YJ, Liu XW, Li B, Li SH, Kong XJ, Qin Z, Li JY. Simultaneous determination of diaveridine, trimethoprim and ormetoprim in feed using high performance liquid chromatography tandem mass spectrometry. Food Chem. 2016 Dec 1;212:358-66. doi: 10.1016/j.foodchem.2016.05.184. Epub 2016 Jun 1. PubMed PMID: 27374543. 9: Ono T, Sekiya T, Takahashi Y, Sasaki YF, Izumiyama F, Nishidate E, Tsuda S, Ohta T. The genotoxicity of diaveridine and trimethoprim. Environ Toxicol Pharmacol. 1997 Sep;3(4):297-306. PubMed PMID: 21781790. 10: Tanabe A, Kondo Y, Toriumi T. [Effect of sulfaquinoxaline and diaveridine on leucocytozoon infection in chickens]. Nihon Yakurigaku Zasshi. 1985 Dec;86(6):411-5. Japanese. PubMed PMID: 3937804. 11: Tömpe P, Giegler G. [Polarographic determination of diaveridine in biological samples]. Acta Pharm Hung. 1990 Jan;60(1):23-9. Hungarian. PubMed PMID: 2327254. 12: Carroll PT, Robb CA, Tippett LO, Langston JB. Antibacterial activity of diaveridine, trimethoprim, and selected sulfonamides in prostatic fluid. Invest Urol. 1971 May;8(6):686-94. PubMed PMID: 4996092. 13: Lämmler G, Dürr U. [Chemotherapy of liver coccidiosis in the rabbit using sulfadimethoxine-diaveridine]. Berl Munch Tierarztl Wochenschr. 1969 Dec 15;82(24):480-4. German. PubMed PMID: 5408000. 14: Sakano T, Masuda S, Amano T. Determination of residual diaveridine and sulfaquinoxaline in Hen's egg, chicken plasma and tissues by high-performance liquid chromatography. Chem Pharm Bull (Tokyo). 1981 Aug;29(8):2290-5. PubMed PMID: 7318037. 15: Yoshimura H. Mutagenicity of the coccidiostat diaveridine in the Salmonella/mammalian microsome assay. Mutat Res. 1991 Oct;261(2):149-52. PubMed PMID: 1922158. 16: Tarozzi F. [Combination of anticoccidial drugs: experimental studies of the efficacy of the sulfachloropyrazine-diaveridine-ethopabate combination in the prevention of avian coccidiosis]. Folia Vet Lat. 1974 Apr-Jun;4(2):275-86. Italian. PubMed PMID: 4435681. 17: Sivajothi S, Reddy BS, Rayulu VC. Study on impression smears of hepatic coccidiosis in rabbits. J Parasit Dis. 2016 Sep;40(3):906-9. doi: 10.1007/s12639-014-0602-8. Epub 2014 Oct 30. PubMed PMID: 27605807; PubMed Central PMCID: PMC4996215. 18: Robb CA, Carroll PT, Tippett LO, Langston JB. The diffusion of selected sulfonamides, trimethoprim, and diaveridine into prostatic fluid of dogs. Invest Urol. 1971 May;8(6):679-85. PubMed PMID: 4931079. 19: Gao Y, Zhang Z, Liu X, Lu X, Yan H, He Y, Yang D, Yun H. [Determination of sulfonamide potentiators in animal origin foods by ultra performance liquid chromatography-tandem mass spectrometry]. Se Pu. 2014 May;32(5):524-8. Chinese. PubMed PMID: 25185314. 20: Rehm WF, Weiser H. [The effect of sulfadimethoxine in combination with diaveridine on chicken coccidioses]. Wien Tierarztl Monatsschr. 1968;55(4):221-8. German. PubMed PMID: 5695776.

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