MM-589 is a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)−Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. MM-589 binds to WDR5 with an IC50 value of 0.90 nM (Ki value <1 nM) and inhibits the MLL H3K4 methyltransferase (HMT) activity with an IC50 value of 12.7 nM. MM-589 potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations and is >40 times better than the previously reported compound MM-401. MM-589 represents the most potent inhibitor of the WDR5−MLL interaction reported to date, and further optimization of MM-589 may yield a new therapy for acute leukemia.
MedKoo Cat#: 407493
Name: MM-589 TFA salt
CAS#: 2097887-21-1 (TFA salt)
Chemical Formula: C30H45F3N8O7
Exact Mass:
Molecular Weight: 686.73
Elemental Analysis: C, 52.47; H, 6.61; F, 8.30; N, 16.32; O, 16.31
The following data is based on the product molecular weight 686.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
