MedKoo Cat#: 533004 | Name: ZK93423

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZK93423 is a potent benzodiazepine receptor agonist (IC50 = 1 nM). ZK93423 is non-selective between α1-, α2-, α3- and α5-subunit containing GABAA receptors (Ki values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [3H]Ro15-1788 binding to human recombinant α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2 receptors respectively).

Chemical Structure

ZK93423
ZK93423
CAS#83910-44-5 (free base)

Theoretical Analysis

MedKoo Cat#: 533004

Name: ZK93423

CAS#: 83910-44-5 (free base)

Chemical Formula: C23H22N2O4

Exact Mass: 390.1580

Molecular Weight: 390.44

Elemental Analysis: C, 70.75; H, 5.68; N, 7.18; O, 16.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
83910-44-5 (free base) 1216574-52-5 (HCl)
Synonym
ZK93423; ZK 93423; ZK-93423.
IUPAC/Chemical Name
ethyl 6-(benzyloxy)-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate
InChi Key
ALBKMJDFBZVHAK-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H22N2O4/c1-3-28-23(26)22-18(14-27-2)21-17-11-16(29-13-15-7-5-4-6-8-15)9-10-19(17)25-20(21)12-24-22/h4-12,25H,3,13-14H2,1-2H3
SMILES Code
O=C(C1=C(COC)C2=C(C=N1)NC3=C2C=C(OCC4=CC=CC=C4)C=C3)OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 390.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ferretti V, Gilli P, Borea PA. Structural features controlling the binding of beta-carbolines to the benzodiazepine receptor. Acta Crystallogr B. 2004 Aug;60(Pt 4):481-9. Epub 2004 Jul 19. PubMed PMID: 15258407. 2: Zhang H, Larock RC. Synthesis of beta- and gamma-carbolines by the palladium-catalyzed iminoannulation of alkynes. J Org Chem. 2002 Dec 27;67(26):9318-30. PubMed PMID: 12492334. 3: Davies M, Bateson AN, Dunn SM. Structural requirements for ligand interactions at the benzodiazepine recognition site of the GABA(A) receptor. J Neurochem. 1998 May;70(5):2188-94. PubMed PMID: 9572307. 4: Rodgers RJ, Randall JI. Are the analgesic effects of social defeat mediated by benzodiazepine receptors? Physiol Behav. 1987;41(3):279-89. PubMed PMID: 2829247.