TAK-137 | CAS#1358749-55-9 | AMPA receptor potentiator

MedKoo Cat#: 463693 | Name: TAK-137

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TAK-137 is a novel AMPA receptor potentiator with little agonistic effect, producing antidepressant-like effect without causing psychotomimetic effects.

Chemical Structure

TAK-137

CAS#1358749-55-9

Theoretical Analysis

MedKoo Cat#: 463693

Name: TAK-137

CAS#: 1358749-55-9

Chemical Formula: C19H16N2O3S

Exact Mass: 352.0882

Molecular Weight: 352.41

Elemental Analysis: C, 64.76; H, 4.58; N, 7.95; O, 13.62; S, 9.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

TAK-137; TAK137; TAK 137;

IUPAC/Chemical Name

9-(4-phenoxyphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide

InChi Key

VKKLOYOLCCDGLD-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H16N2O3S/c22-25(23)14-13-21-12-4-7-18(19(21)20-25)15-8-10-17(11-9-15)24-16-5-2-1-3-6-16/h1-12H,13-14H2

SMILES Code

O=S1(N=C(C(C2=CC=C(OC3=CC=CC=C3)C=C2)=CC=C4)N4CC1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 352.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Suzuki A, Tajima Y, Kunugi A, Kimura H. Electrophysiological characterization of a novel AMPA receptor potentiator, TAK-137, in rat hippocampal neurons. Neurosci Lett. 2019 Nov 1;712:134488. doi: 10.1016/j.neulet.2019.134488. Epub 2019 Sep 10. PMID: 31518676. 2: Suzuki A, Murakami K, Tajima Y, Hara H, Kunugi A, Kimura H. TAK-137, an AMPA receptor potentiator with little agonistic effect, produces antidepressant-like effect without causing psychotomimetic effects in rats. Pharmacol Biochem Behav. 2019 Aug;183:80-86. doi: 10.1016/j.pbb.2019.06.004. Epub 2019 Jun 13. PMID: 31202810. 3: Tanaka M, Kunugi A, Suzuki A, Suzuki N, Suzuki M, Kimura H. Preclinical characterization of AMPA receptor potentiator TAK-137 as a therapeutic drug for schizophrenia. Pharmacol Res Perspect. 2019 May 9;7(3):e00479. doi: 10.1002/prp2.479. PMID: 31086673; PMCID: PMC6507438. 4: Kunugi A, Tanaka M, Suzuki A, Tajima Y, Suzuki N, Suzuki M, Nakamura S, Kuno H, Yokota A, Sogabe S, Kosugi Y, Awasaki Y, Kaku T, Kimura H. TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window. Neuropsychopharmacology. 2019 Apr;44(5):961-970. doi: 10.1038/s41386-018-0213-7. Epub 2018 Sep 12. PMID: 30209408; PMCID: PMC6461786.