Terbutaline Sulfate | CAS#23031-25-6 | CAS#23031-32-5 | beta-2 Adrenergic Receptor Agonist

MedKoo Cat#: 329667 | Name: Terbutaline sulfate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Terbutaline is a selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic. Terbutaline is used as a fast-acting bronchodilator (often used as a short-term asthma treatment) and as a tocolytic[4] to delay premature labor. The inhaled form of terbutaline starts working within 15 minutes and can last up to 6 hours.

Chemical Structure

Terbutaline sulfate

CAS#23031-32-5 (sulfate)

Theoretical Analysis

MedKoo Cat#: 329667

Name: Terbutaline sulfate

CAS#: 23031-32-5 (sulfate)

Chemical Formula: C24H40N2O10S

Exact Mass: 0.0000

Molecular Weight: 548.65

Elemental Analysis: C, 52.54; H, 7.35; N, 5.11; O, 29.16; S, 5.84

Price and Availability

Size	Price	Availability
1g	USD 350.00	2 weeks
2g	USD 600.00	2 weeks
5g	USD 950.00	2 weeks

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Related CAS #

23031-32-5 (sulfate) 23031-25-6 (free base)

Synonym

KWD 2019; KWD-2019; KWD2019; Terbutaline sulfate; Bronclyn, Brethine, Bricanyl, Brethaire, Terbulin.

IUPAC/Chemical Name

5-(2-(tert-butylamino)-1-hydroxyethyl)benzene-1,3-diol; sulfate (2:1)

InChi Key

KFVSLSTULZVNPG-UHFFFAOYSA-N

InChi Code

InChI=1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)

SMILES Code

OC1=CC(C(O)CNC(C)(C)C)=CC(O)=C1.OC2=CC(C(O)CNC(C)(C)C)=CC(O)=C2.O=S(O)(O)=O

Appearance

White to off-white crystalline powder.

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 548.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Martin C, Cocchio C. Effect of phenylephrine and terbutaline on ischemic priapism: a retrospective review. Am J Emerg Med. 2016 Feb;34(2):222-4. doi: 10.1016/j.ajem.2015.10.029. Epub 2015 Oct 24. Review. PubMed PMID: 26597497. 2: Chawanpaiboon S, Laopaiboon M, Lumbiganon P, Sangkomkamhang US, Dowswell T. Terbutaline pump maintenance therapy after threatened preterm labour for reducing adverse neonatal outcomes. Cochrane Database Syst Rev. 2014 Mar 23;(3):CD010800. doi: 10.1002/14651858.CD010800.pub2. Review. PubMed PMID: 24659357. 3: Elliott JP, Morrison JC, Chauhan SP. A critical appraisal of the potential harmful effects of terbutaline sulfate use in pregnancy. J Reprod Med. 2013 Mar-Apr;58(3-4):123-31. Review. PubMed PMID: 23539880. 4: Gaudet LM, Singh K, Weeks L, Skidmore B, Tsertsvadze A, Ansari MT. Effectiveness of terbutaline pump for the prevention of preterm birth. A systematic review and meta-analysis. PLoS One. 2012;7(2):e31679. doi: 10.1371/journal.pone.0031679. Epub 2012 Feb 21. Review. PubMed PMID: 22363704; PubMed Central PMCID: PMC3283660. 5: Gaudet L, Singh K, Weeks L, Skidmore B, Tsouros S, Tsertsvadze A, Daniel R, Doucette S, Walker M, Ansari M. Terbutaline Pump for the Prevention of Preterm Birth [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Sep. Available from http://www.ncbi.nlm.nih.gov/books/NBK82399/ PubMed PMID: 22191109. 6: Jones GH, Scott SJ. Continuous infusions of terbutaline in asthma - a review. J Asthma. 2011 Oct;48(8):753-6. doi: 10.3109/02770903.2011.613509. Review. PubMed PMID: 21942352. 7: Enderle J, Jones J. Towards evidence based emergency medicine: Best BETs from the Manchester Royal Infirmary. Bet 1: The effectiveness of oral terbutaline in treatment of priapism. Emerg Med J. 2011 Jun;28(6):533-4. doi: 10.1136/emj.2011.114850. Review. PubMed PMID: 21602169. 8: Nanda K, Cook LA, Gallo MF, Grimes DA. Terbutaline pump maintenance therapy after threatened preterm labor for preventing preterm birth. Cochrane Database Syst Rev. 2002;(4):CD003933. Review. PubMed PMID: 12519621. 9: Lam F, Elliott J, Jones JS, Katz M, Knuppel RA, Morrison J, Newman R, Phelan J, Willcourt R. Clinical issues surrounding the use of terbutaline sulfate for preterm labor. Obstet Gynecol Surv. 1998 Nov;53(11 Suppl):S85-95. Review. PubMed PMID: 9812326. 10: Sisson MC. Preventing preterm labor. Is terbutaline our best option? AWHONN Lifelines. 1997 Apr;1(2):42-6. Review. PubMed PMID: 9208748. 11: Quinn PG, Sherman BW, Tavill AS, Gibas AL. Terbutaline hepatitis in pregnancy: report of two cases and literature review. Am J Gastroenterol. 1994 May;89(5):781-4. Review. PubMed PMID: 8172156. 12: Cowan M. Home care of the pregnant woman using terbutaline. MCN Am J Matern Child Nurs. 1993 Mar-Apr;18(2):99-105. Review. PubMed PMID: 8492654. 13: Hochhaus G, Möllmann H. Pharmacokinetic/pharmacodynamic characteristics of the beta-2-agonists terbutaline, salbutamol and fenoterol. Int J Clin Pharmacol Ther Toxicol. 1992 Sep;30(9):342-62. Review. PubMed PMID: 1358833. 14: Scoggin CH. Aerosolized terbutaline sulfate in the treatment of bronchospasm. Clin Ther. 1984;6(5):603-12. Review. PubMed PMID: 6434183. 15: Kaik G, Bonelli J, Hitzenberger G, Laggner A, Magometschnigg D. [Pulmonary function tests with the bronchodilator Terbutaline]. Acta Med Austriaca Suppl. 1979;14:1-39. Review. German. PubMed PMID: 161461.