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MedKoo Cat#: 525860 | Name: SGM8

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SGM8 is a novel Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions.

Chemical Structure

SGM8
SGM8
CAS#882268-09-9

Theoretical Analysis

MedKoo Cat#: 525860

Name: SGM8

CAS#: 882268-09-9

Chemical Formula: C12H15NOS2

Exact Mass: 253.0595

Molecular Weight: 253.38

Elemental Analysis: C, 56.88; H, 5.97; N, 5.53; O, 6.31; S, 25.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SGM8
IUPAC/Chemical Name
5-(Dimethylamino)methylene-3-(methylthio)-6,7-dihydrobenzo[c]thiophen-4(5H)-one
InChi Key
SBORPYWLRSWZTD-SOFGYWHQSA-N
InChi Code
InChI=1S/C12H15NOS2/c1-13(2)6-8-4-5-9-7-16-12(15-3)10(9)11(8)14/h6-7H,4-5H2,1-3H3/b8-6+
SMILES Code
O=C(C1=C(SC)SC=C1CC/2)C2=C\N(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 253.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen H, Coseno M, Ficarro SB, Mansueto MS, Komazin-Meredith G, Boissel S, Filman DJ, Marto JA, Hogle JM, Coen DM. A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS Infect Dis. 2017 Feb 10;3(2):112-118. doi: 10.1021/acsinfecdis.6b00079. Epub 2016 Dec 6. PubMed PMID: 28183184. 2: Moreno SG, Sutton AJ, Turner EH, Abrams KR, Cooper NJ, Palmer TM, Ades AE. Novel methods to deal with publication biases: secondary analysis of antidepressant trials in the FDA trial registry database and related journal publications. BMJ. 2009 Aug 7;339:b2981. doi: 10.1136/bmj.b2981. Review. PubMed PMID: 19666685; PubMed Central PMCID: PMC2723217. 3: Moreno SG, Sutton AJ, Ades AE, Stanley TD, Abrams KR, Peters JL, Cooper NJ. Assessment of regression-based methods to adjust for publication bias through a comprehensive simulation study. BMC Med Res Methodol. 2009 Jan 12;9:2. doi: 10.1186/1471-2288-9-2. PubMed PMID: 19138428; PubMed Central PMCID: PMC2649158.