Synonym
Auten-99; Auten 99; Auten99; Auten-99 hydrobromide; Auten-99 HBr; Autophagy Enhancer-99
IUPAC/Chemical Name
2-Biphenyl-4-yl-5,6-dihydro-imidazo[2,1-b]thiazole hydrobromide
InChi Key
FYYVGPJPIJHFCL-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H14N2S.BrH/c1-2-4-13(5-3-1)14-6-8-15(9-7-14)16-12-19-11-10-18-17(19)20-16;/h1-9,12H,10-11H2;1H
SMILES Code
[H]Br.C12=NCCN1C=C(C3=CC=C(C4=CC=CC=C4)C=C3)S2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
359.28
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kovács T, Billes V, Komlós M, Hotzi B, Manzéger A, Tarnóci A, Papp D, Szikszai F, Szinyákovics J, Rácz Á, Noszál B, Veszelka S, Walter FR, Deli MA, Hackler L Jr, Alfoldi R, Huzian O, Puskas LG, Liliom H, Tárnok K, Schlett K, Borsy A, Welker E, Kovács AL, Pádár Z, Erdős A, Legradi A, Bjelik A, Gulya K, Gulyás B, Vellai T. The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Sci Rep. 2017 Feb 16;7:42014. doi: 10.1038/srep42014. PMID: 28205624; PMCID: PMC5311965.
2: Komlós M, Szinyákovics J, Falcsik G, Sigmond T, Jezsó B, Vellai T, Kovács T. The Small-Molecule Enhancers of Autophagy AUTEN-67 and -99 Delay Ageing in Drosophila Striated Muscle Cells. Int J Mol Sci. 2023 Apr 30;24(9):8100. doi: 10.3390/ijms24098100. PMID: 37175806; PMCID: PMC10179358.
