VU0469650 is a potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM). VU0469650 demonstrated an excellent selectivity profile and good exposure in both plasma and brain samples following intraperitoneal dosing in rats.
MedKoo Cat#: 532949
Name: VU0469650
CAS#: 1443748-47-7
Chemical Formula: C22H28N4O
Exact Mass: 364.2263
Molecular Weight: 364.49
Elemental Analysis: C, 72.50; H, 7.74; N, 15.37; O, 4.39
The following data is based on the product molecular weight 364.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
