MedKoo Cat#: 532881 | Name: VPC171
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VPC171 is a positive allosteric modulator (PAM) of the adenosine A1 receptor (A1R). PAMs of the A1R are being investigated as a novel treatment approach for neuropathic pain.

Chemical Structure

VPC171
VPC171
CAS#1018830-99-3

Theoretical Analysis

MedKoo Cat#: 532881

Name: VPC171

CAS#: 1018830-99-3

Chemical Formula: C18H12F3NOS

Exact Mass: 347.0592

Molecular Weight: 347.36

Elemental Analysis: C, 62.24; H, 3.48; F, 16.41; N, 4.03; O, 4.61; S, 9.23

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
50mg USD 1,010.00 2 Weeks
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Related CAS #
No Data
Synonym
VPC171; VPC 171; VPC-171;
IUPAC/Chemical Name
[2-amino-4-[3-(trifluoromethyl)phenyl]thiophen-3-yl]-phenylmethanone
InChi Key
HNHLVOBHWXLIGP-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H12F3NOS/c19-18(20,21)13-8-4-7-12(9-13)14-10-24-17(22)15(14)16(23)11-5-2-1-3-6-11/h1-10H,22H2
SMILES Code
O=C(C1=C(N)SC=C1C2=CC=CC(C(F)(F)F)=C2)C3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 347.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Aurelio L, Valant C, Flynn BL, Sexton PM, Christopoulos A, Scammells PJ. (2009) Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes. J. Med. Chem., 52 (14): 4543-7. [PMID:19514747] 2. Imlach WL, Bhola RF, May LT, Christopoulos A, Christie MJ. (2015) A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model. Mol. Pharmacol., 88 (3): 460-8. [PMID:26104547]