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MedKoo Cat#: 463269 | Name: Redoxal

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Redoxal is a novel Prenyltransferase Inhibitor with In Vitro and In Vivo Antibacterial Activity.

Chemical Structure

Redoxal
Redoxal
CAS#52962-95-5

Theoretical Analysis

MedKoo Cat#: 463269

Name: Redoxal

CAS#: 52962-95-5

Chemical Formula: C28H24N2O6

Exact Mass: 484.1634

Molecular Weight: 484.51

Elemental Analysis: C, 69.41; H, 4.99; N, 5.78; O, 19.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Redoxal;
IUPAC/Chemical Name
2,2'-((3,3'-dimethoxy-[1,1'-biphenyl]-4,4'-diyl)bis(azanediyl))dibenzoic acid
InChi Key
IQZIRNIZQHVBMB-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H24N2O6/c1-35-25-15-17(11-13-23(25)29-21-9-5-3-7-19(21)27(31)32)18-12-14-24(26(16-18)36-2)30-22-10-6-4-8-20(22)28(33)34/h3-16,29-30H,1-2H3,(H,31,32)(H,33,34)
SMILES Code
COC1=CC(C2=CC=C(NC3=CC=CC=C3C(O)=O)C(OC)=C2)=CC=C1NC4=CC=CC=C4C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 484.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Song J, Malwal SR, Baig N, Schurig-Briccio LA, Gao Z, Vaidya GS, Yang K, Abutaleb NS, Seleem MN, Gennis RB, Pogorelov TV, Oldfield E, Feng X. Discovery of Prenyltransferase Inhibitors with In Vitro and In Vivo Antibacterial Activity. ACS Infect Dis. 2020 Oct 21. doi: 10.1021/acsinfecdis.0c00472. Epub ahead of print. PMID: 33085463. 2: Pery E, Sheehy A, Miranda Nebane N, Misra V, Mankowski MK, Rasmussen L, Lucile White E, Ptak RG, Gabuzda D. Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1. Virology. 2015 Oct;484:276-87. doi: 10.1016/j.virol.2015.06.014. Epub 2015 Jul 1. PMID: 26141568; PMCID: PMC4567410. 3: Setzer B, Lebrecht D, Walker UA. Pyrimidine nucleoside depletion sensitizes to the mitochondrial hepatotoxicity of the reverse transcriptase inhibitor stavudine. Am J Pathol. 2008 Mar;172(3):681-90. doi: 10.2353/ajpath.2008.070613. Epub 2008 Feb 14. PMID: 18276780; PMCID: PMC2258259. 4: Zameitat E, Gojković Z, Knecht W, Piskur J, Löffler M. Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans. FEBS J. 2006 Jul;273(14):3183-91. doi: 10.1111/j.1742-4658.2006.05327.x. Epub 2006 Jun 15. PMID: 16774642. 5: Boz A, Evliyaoğlu O, Yildirim M, Erkan N, Karaca B. The value of serum zinc, copper, ceruloplasmin levels in patients with gastrointestinal tract cancers. Turk J Gastroenterol. 2005 Jun;16(2):81-4. PMID: 16252197. 6: Löffler M, Knecht W, Rawls J, Ullrich A, Dietz C. Drosophila melanogaster dihydroorotate dehydrogenase: the N-terminus is important for biological function in vivo but not for catalytic properties in vitro. Insect Biochem Mol Biol. 2002 Sep;32(9):1159-69. doi: 10.1016/s0965-1748(02)00052-8. PMID: 12213251. 7: Baldwin J, Farajallah AM, Malmquist NA, Rathod PK, Phillips MA. Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity. J Biol Chem. 2002 Nov 1;277(44):41827-34. doi: 10.1074/jbc.M206854200. Epub 2002 Aug 19. PMID: 12189151. 8: Ullrich A, Knecht W, Fries M, Löffler M. Recombinant expression of N-terminal truncated mutants of the membrane bound mouse, rat and human flavoenzyme dihydroorotate dehydrogenase. A versatile tool to rate inhibitor effects? Eur J Biochem. 2001 Mar;268(6):1861-8. PMID: 11248707. 9: Knecht W, Löffler M. Redoxal as a new lead structure for dihydroorotate dehydrogenase inhibitors: a kinetic study of the inhibition mechanism. FEBS Lett. 2000 Feb 4;467(1):27-30. doi: 10.1016/s0014-5793(00)01117-0. PMID: 10664450. 10: Cleaveland ES, Monks A, Vaigro-Wolff A, Zaharevitz DW, Paull K, Ardalan K, Cooney DA, Ford H Jr. Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the compare program. Biochem Pharmacol. 1995 Mar 30;49(7):947-54. doi: 10.1016/0006-2952(95)00009-o. PMID: 7741767.